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10.1093/ecco-jcc/jjaa137 http://scihub22266oqcxt.onion/10.1093/ecco-jcc/jjaa137 32598438!7337665!32598438     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32598438&cmd=llinks): Failed to open stream: HTTP request failed! 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Clinical Trials and Tribulations : The Immediate Effects of COVID-19 on IBD Clinical Research Activity in the UK |pdf=|usr=}}{{32598438}} gab.com Text Clinical Trials and Tribulations : The Immediate Effects of COVID-19 on IBD Clinical Research Activity in the UK JO: J Crohns Colitis http://www.kidney.de/pget.php?&tw=1&pmid=32598438 #FOAvip There have been immediate and profound impacts of SARS-CoV-2 and COVID-19 on health care services worldwide, with major consequences for non COVID-19 related health care. Alongside efforts to reconfigure services and enable continued delivery of safe clinical care for patients with IBD, consideration must also be given to management of IBD research activity. In many centres there has been an effective shutdown of IBD clinical trial activity as research sites have switched focus to either COVID-19 related research or clinical care only. As a result, the early termination of trial programmes, and loss of potentially effective therapeutic options for IBD, has become a real and worrying prospect. Moreover, in many countries research activity has become embedded into clinical care-with clinical trials often providing access to new therapies or strategies-which would otherwise not have been available in standard clinical pathways. This pandemic has significant implications for the design, conduct, analysis, and reporting of clinical trials in IBD. In this Viewpoint, we share our experiences from a clinical and academic perspective in the UK, highlighting the early challenges encountered, and consider implications for patients and staff at research sites, sponsors, research ethics committees, funders, and regulators. We also offer potential solutions both for now and for when we enter a recovery phase from the pandemic. Twit Text FOAVip Clinical Trials and Tribulations : The Immediate Effects of COVID-19 on IBD Clinical Research Activity in the UK ????J Crohns Colitis http://www.kidney.de/pget.php?&tw=1&pmid=32598438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32598438 #FOAvip English Wikipedia <ref>{{Cite pmid|32598438}}</ref> Clinical Trials and Tribulations : The Immediate Effects of COVID-19 on IBD Clinical Research Activity in the UK #MMPMID32598438 Noor NM; Hart AL; Irving PM; Ghosh S; Parkes M; Raine T J Crohns Colitis 2020[Dec]; 14 (12): 1769-1776 PMID32598438show ga There have been immediate and profound impacts of SARS-CoV-2 and COVID-19 on health care services worldwide, with major consequences for non COVID-19 related health care. Alongside efforts to reconfigure services and enable continued delivery of safe clinical care for patients with IBD, consideration must also be given to management of IBD research activity. In many centres there has been an effective shutdown of IBD clinical trial activity as research sites have switched focus to either COVID-19 related research or clinical care only. As a result, the early termination of trial programmes, and loss of potentially effective therapeutic options for IBD, has become a real and worrying prospect. Moreover, in many countries research activity has become embedded into clinical care-with clinical trials often providing access to new therapies or strategies-which would otherwise not have been available in standard clinical pathways. This pandemic has significant implications for the design, conduct, analysis, and reporting of clinical trials in IBD. In this Viewpoint, we share our experiences from a clinical and academic perspective in the UK, highlighting the early challenges encountered, and consider implications for patients and staff at research sites, sponsors, research ethics committees, funders, and regulators. We also offer potential solutions both for now and for when we enter a recovery phase from the pandemic. |COVID-19/*prevention & control[MESH] |Clinical Trials as Topic/methods/*statistics & numerical data[MESH] |Health Services Accessibility/*trends[MESH] |Humans[MESH] |Inflammatory Bowel Diseases/*therapy[MESH] |Patient Selection[MESH] |Research Design/trends[MESH]Clinical Trials and Tribulations : The Immediate Effects of COVID-19 (epmc).pdf DeepDyve Pubget Overpricing