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10.1111/tbed.13710 http://scihub22266oqcxt.onion/10.1111/tbed.13710 32619318!7362058!32619318     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32619318.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Transbound+Emerg+Dis 2021 ; 68 (2): 313-317 Nephropedia Template TP {{tp|p=32619318|t=2021. COVID-19 drug repurposing: Summary statistics on current clinical trials and promising untested candidates |pdf=|usr=}}{{32619318}} gab.com Text COVID-19 drug repurposing: Summary statistics on current clinical trials and promising untested candidates JO: Transbound Emerg Dis http://www.kidney.de/pget.php?&tw=1&pmid=32619318 #FOAvip Repurposing of existing anti-viral drugs, immunological modulators and supportive therapies represents a promising path towards rapidly developing new control strategies to mitigate the devastating public health consequences of the COVID-19 pandemic. A comprehensive text-mining and manual curation approach was used to comb and summarize the most pertinent information from existing clinical trials and previous efforts to develop therapies against related betacoronaviruses, particularly SARS and MERS. In contrast to drugs in current trials, which have been derived overwhelmingly from studies on taxonomically unrelated RNA viruses, a number of untested small molecule anti-virals had previously demonstrated remarkable in vitro specificity for SARS-CoV or MERS-CoV, with high selectivity indices, EC(50) and/or IC(50) . Due to the rapid containment of the prior epidemics, however, these were generally not followed up with in vivo animal studies or clinical investigations and thus largely overlooked as treatment prospects in the current COVID-19 trials. This brief review summarizes and tabulates core information on recent or ongoing drug repurposing-focused clinical trials, while detailing the most promising untested candidates with prior documented success against the aetiologic agents of SARS and/or MERS. Twit Text FOAVip COVID-19 drug repurposing: Summary statistics on current clinical trials and promising untested candidates ????Transbound Emerg Dis http://www.kidney.de/pget.php?&tw=1&pmid=32619318 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32619318 #FOAvip English Wikipedia <ref>{{Cite pmid|32619318}}</ref> COVID-19 drug repurposing: Summary statistics on current clinical trials and promising untested candidates #MMPMID32619318 Ulm JW; Nelson SF Transbound Emerg Dis 2021[Mar]; 68 (2): 313-317 PMID32619318show ga Repurposing of existing anti-viral drugs, immunological modulators and supportive therapies represents a promising path towards rapidly developing new control strategies to mitigate the devastating public health consequences of the COVID-19 pandemic. A comprehensive text-mining and manual curation approach was used to comb and summarize the most pertinent information from existing clinical trials and previous efforts to develop therapies against related betacoronaviruses, particularly SARS and MERS. In contrast to drugs in current trials, which have been derived overwhelmingly from studies on taxonomically unrelated RNA viruses, a number of untested small molecule anti-virals had previously demonstrated remarkable in vitro specificity for SARS-CoV or MERS-CoV, with high selectivity indices, EC(50) and/or IC(50) . Due to the rapid containment of the prior epidemics, however, these were generally not followed up with in vivo animal studies or clinical investigations and thus largely overlooked as treatment prospects in the current COVID-19 trials. This brief review summarizes and tabulates core information on recent or ongoing drug repurposing-focused clinical trials, while detailing the most promising untested candidates with prior documented success against the aetiologic agents of SARS and/or MERS. |*COVID-19 Drug Treatment[MESH] |*Drug Repositioning[MESH] |*Pandemics[MESH] |*SARS-CoV-2[MESH] |Animals[MESH] |Antiviral Agents/*therapeutic use[MESH] |Clinical Trials as Topic[MESH]COVID-19 drug repurposing: Summary statistics on current clinical tria(epmc).pdf DeepDyve Pubget Overpricing