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10.1007/s40620-020-00794-1

http://scihub22266oqcxt.onion/10.1007/s40620-020-00794-1
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32621109!7333370!32621109
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suck abstract from ncbi


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pmid32621109      J+Nephrol 2020 ; 33 (4): 725-736
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  • Exposure to novel coronavirus in patients on renal replacement therapy during the exponential phase of COVID-19 pandemic: survey of the Italian Society of Nephrology #MMPMID32621109
  • Quintaliani G; Reboldi G; Di Napoli A; Nordio M; Limido A; Aucella F; Messa P; Brunori G
  • J Nephrol 2020[Aug]; 33 (4): 725-736 PMID32621109show ga
  • BACKGROUND: Between February and April 2020, Italy experienced an overwhelming growth of the COVID-19 pandemic. Little is known, at the country level, where and how patients on renal replacement therapy (RRT) have been mostly affected. METHODS: Survey of the network of Nephrology centers using a simplified 17 items electronic questionnaire designed by Italian Society of Nephrology COVID-19 Research Group. We used spatial epidemiology and geographical information systems to map SARS-CoV-2 spread among RRT patients in Italy. RESULTS: On April 9th 2020, all nephrology centers (n = 454) listed in the DialMap database were invited to complete the electronic questionnaire. Within 11 days on average, 365 centers responded (80.4% response rate; 2.3% margin of error) totaling 60,441 RRT patients. The surveyed RRT population included 30,821 hemodialysis (HD), 4139 peritoneal dialysis (PD), and 25,481 transplanted (Tx) patients respectively. The proportion of SARS-CoV-2 positive RRT patients in Italy was 2.26% (95% CI 2.14-2.39) with significant differences according to treatment modality (p < 0.001). The proportion of patients positive for SARS-CoV-2 was significantly higher in HD (3.55% [95% CI 3.34-3.76]) than PD (1.38% [95% CI 1.04-1.78] and Tx (0.86% [95% CI 0.75-0.98]) (p < 0.001), with substantial heterogeneity across regions and along the latitude gradient (p < 0.001). In RRT patients the highest rate was in the north-west (4.39% [95% CI 4.11-4.68], followed by the north-east (IR 2.06% [1.79-2.36]), the center (0.91% [0.75-1.09]), the main islands (0.67% [0.47-0.93]), and the south (0.59% [0.45-0.75]. During the COVID-19 pandemic, among SARS-Cov-2 positive RRT patients the fatality rate was 32.8%, as compared to 13.3% observed in the Italian population as of April 23rd. CONCLUSIONS: A substantial proportion of the 60,441 surveyed RRT patients in Italy were SARS-Cov-2 positive and subsequently died during the exponential phase of COVID-19 pandemic. Infection risk and rates seems to differ substantially across regions, along geographical latitude, and by treatment modality.
  • |*Betacoronavirus[MESH]
  • |*Renal Replacement Therapy[MESH]
  • |COVID-19[MESH]
  • |Coronavirus Infections/*epidemiology/mortality[MESH]
  • |Humans[MESH]
  • |Kidney Transplantation[MESH]
  • |Nephrology[MESH]
  • |Pandemics[MESH]
  • |Peritoneal Dialysis[MESH]
  • |Pneumonia, Viral/*epidemiology/mortality[MESH]
  • |SARS-CoV-2[MESH]
  • |Societies, Medical[MESH]


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