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10.1111/eci.13342 http://scihub22266oqcxt.onion/10.1111/eci.13342 32645207!7404583!32645207     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32645207&cmd=llinks): Failed to open stream: HTTP request failed! 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Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases |pdf=|usr=}}{{32645207}} gab.com Text Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases JO: Eur J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=32645207 #FOAvip COVID-19 pandemia is a major concern for patients and healthcare systems. The fear of infection by patients with concomitant rheumatic diseases (either adult or children) and connective tissue diseases is arising worldwide, because of their immunological background and immunological therapies. Analysing the basic biology of single diseases, the data suggest that there is an "immunological umbrella" that seems to protect against the infection, through IFN type 1 and NK cell function. To date, reports from China, United States and Europe did not reveal an higher risk of infection, either for rheumatoid arthritis, juvenile idiopathic arthritis nor for lupus erythematosus. Antimalarials, anti-IL6-Anti-IL6 receptor, anti-IL1, anti-GM-CSF receptor and JAK1/2/3 inhibitors, are under investigation in COVID-dedicated clinical trials to control the inflammation raised by SARS-CoV-2 infection. Initial reports on the occurrence of autoimmune phenomena in the convalescence phase of SARS-CoV-2 infection suggests that the immunological consequences of the infection need to be strictly understood. Reporting of the study conforms to broad EQUATOR guidelines (Simera et al January 2010 issue of EJCI). Twit Text FOAVip Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases ????Eur J Clin Invest http://www.kidney.de/pget.php?&tw=1&pmid=32645207 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32645207 #FOAvip English Wikipedia <ref>{{Cite pmid|32645207}}</ref> Basic immunology may lead to translational therapeutic rationale: SARS-CoV-2 and rheumatic diseases #MMPMID32645207 Gremese E; Ferraccioli ES; Alivernini S; Tolusso B; Ferraccioli G Eur J Clin Invest 2020[Sep]; 50 (9): e13342 PMID32645207show ga COVID-19 pandemia is a major concern for patients and healthcare systems. The fear of infection by patients with concomitant rheumatic diseases (either adult or children) and connective tissue diseases is arising worldwide, because of their immunological background and immunological therapies. Analysing the basic biology of single diseases, the data suggest that there is an "immunological umbrella" that seems to protect against the infection, through IFN type 1 and NK cell function. To date, reports from China, United States and Europe did not reveal an higher risk of infection, either for rheumatoid arthritis, juvenile idiopathic arthritis nor for lupus erythematosus. Antimalarials, anti-IL6-Anti-IL6 receptor, anti-IL1, anti-GM-CSF receptor and JAK1/2/3 inhibitors, are under investigation in COVID-dedicated clinical trials to control the inflammation raised by SARS-CoV-2 infection. Initial reports on the occurrence of autoimmune phenomena in the convalescence phase of SARS-CoV-2 infection suggests that the immunological consequences of the infection need to be strictly understood. Reporting of the study conforms to broad EQUATOR guidelines (Simera et al January 2010 issue of EJCI). |Adaptive Immunity/drug effects/immunology[MESH] |Aged[MESH] |Antirheumatic Agents/administration & dosage[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Comorbidity[MESH] |Coronavirus Infections/drug therapy/*epidemiology/*immunology[MESH] |Disease Outbreaks/statistics & numerical data[MESH] |Female[MESH] |Humans[MESH] |Hydroxychloroquine/administration & dosage[MESH] |Immunity, Innate/drug effects/immunology[MESH] |Immunologic Factors/administration & dosage[MESH] |Immunosuppressive Agents/*administration & dosage[MESH] |Italy/epidemiology[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/drug therapy/*epidemiology/*immunology[MESH] |Rheumatic Diseases/drug therapy/*epidemiology/immunology[MESH] |Risk Assessment[MESH]Basic immunology may lead to translational therapeutic rationale: SARS(epmc).pdf DeepDyve Pubget Overpricing