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10.1002/cmdc.202000260 http://scihub22266oqcxt.onion/10.1002/cmdc.202000260 32652783!7540527!32652783     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32652783&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32652783.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       ChemMedChem 2020 ; 15 (17): 1661-1671 Nephropedia Template TP {{tp|p=32652783|t=2020. Synthesis of Antiviral Perfluoroalkyl Derivatives of Teicoplanin and Vancomycin |pdf=|usr=}}{{32652783}} gab.com Text Synthesis of Antiviral Perfluoroalkyl Derivatives of Teicoplanin and Vancomycin JO: ChemMedChem http://www.kidney.de/pget.php?&tw=1&pmid=32652783 #FOAvip The limited scope of antiviral drugs and increasing problem of antiviral drug resistance represent a global health threat. Glycopeptide antibiotics and their lipophilic derivatives have emerged as relevant inhibitors of diverse viruses. Herein, we describe a new strategy for the synthesis of dual hydrophobic and lipophobic derivatives of glycopeptides to produce selective antiviral agents without membrane-disrupting activity. Perfluorobutyl and perfluorooctyl moieties were attached through linkers of different length to azido derivatives of vancomycin aglycone and teicoplanin pseudoaglycone, and the new derivatives were evaluated against a diverse panel of viruses. The teicoplanin derivatives displayed strong anti-influenza virus activity at nontoxic concentrations. Some of the perfluoroalkylated glycopeptides were also active against a few other viruses such as herpes simplex virus or coronavirus. These data encourage further exploration of glycopeptide analogues for broad antiviral application. Twit Text FOAVip Synthesis of Antiviral Perfluoroalkyl Derivatives of Teicoplanin and Vancomycin ????ChemMedChem http://www.kidney.de/pget.php?&tw=1&pmid=32652783 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32652783 #FOAvip English Wikipedia <ref>{{Cite pmid|32652783}}</ref> Synthesis of Antiviral Perfluoroalkyl Derivatives of Teicoplanin and Vancomycin #MMPMID32652783 Bereczki I; Csavas M; Szucs Z; Roth E; Batta G; Ostorhazi E; Naesens L; Borbas A; Herczegh P ChemMedChem 2020[Sep]; 15 (17): 1661-1671 PMID32652783show ga The limited scope of antiviral drugs and increasing problem of antiviral drug resistance represent a global health threat. Glycopeptide antibiotics and their lipophilic derivatives have emerged as relevant inhibitors of diverse viruses. Herein, we describe a new strategy for the synthesis of dual hydrophobic and lipophobic derivatives of glycopeptides to produce selective antiviral agents without membrane-disrupting activity. Perfluorobutyl and perfluorooctyl moieties were attached through linkers of different length to azido derivatives of vancomycin aglycone and teicoplanin pseudoaglycone, and the new derivatives were evaluated against a diverse panel of viruses. The teicoplanin derivatives displayed strong anti-influenza virus activity at nontoxic concentrations. Some of the perfluoroalkylated glycopeptides were also active against a few other viruses such as herpes simplex virus or coronavirus. These data encourage further exploration of glycopeptide analogues for broad antiviral application. |Animals[MESH] |Anti-Bacterial Agents/chemical synthesis/chemistry/pharmacology[MESH] |Antiviral Agents/*chemical synthesis/chemistry/pharmacology[MESH] |Bacillus subtilis/drug effects[MESH] |Catalysis[MESH] |Cell Line[MESH] |Cell Survival/drug effects[MESH] |Coronavirus/drug effects[MESH] |Dogs[MESH] |Fluorocarbons/*chemistry[MESH] |Humans[MESH] |Microbial Sensitivity Tests[MESH] |Palladium/chemistry[MESH] |Staphylococcus aureus/drug effects[MESH] |Structure-Activity Relationship[MESH] |Teicoplanin/*chemistry[MESH] |Vancomycin/*chemistry[MESH]Synthesis of Antiviral Perfluoroalkyl Derivatives of Teicoplanin and V(epmc).pdf DeepDyve Pubget Overpricing