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10.1016/j.chom.2020.07.005 http://scihub22266oqcxt.onion/10.1016/j.chom.2020.07.005 32707096!7368656!32707096     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32707096&cmd=llinks): Failed to open stream: HTTP request failed! 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Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients |pdf=|usr=}}{{32707096}} gab.com Text Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients JO: Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=32707096 #FOAvip Interferons (IFNs) are widely used in treating coronavirus disease 2019 (COVID-19) patients. However, a recent report of ACE2, the host factor mediating SARS-Cov-2 infection, identifying it as interferon-stimulated raised considerable safety concern. To examine the association between the use and timing of IFN-alpha2b and clinical outcomes, we analyzed in a retrospective multicenter cohort study of 446 COVID-19 patients in Hubei, China. Regression models estimated that early administration (</=5 days after admission) of IFN-alpha2b was associated with reduced in-hospital mortality in comparison with no admission of IFN-alpha2b, whereas late administration of IFN-alpha2b was associated with increased mortality. Among survivors, early IFN-alpha2b was not associated with hospital discharge or computed tomography (CT) scan improvement, whereas late IFN-alpha2b was associated with delayed recovery. Additionally, early IFN-alpha2b and umifenovir alone or together were associated with reduced mortality and accelerated recovery in comparison with treatment with lopinavir/ritonavir (LPV/r) alone. We concluded that administration of IFN-alpha2b during the early stage of COVID-19 could induce favorable clinical responses. Twit Text FOAVip Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients ????Cell Host Microbe http://www.kidney.de/pget.php?&tw=1&pmid=32707096 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32707096 #FOAvip English Wikipedia <ref>{{Cite pmid|32707096}}</ref> Retrospective Multicenter Cohort Study Shows Early Interferon Therapy Is Associated with Favorable Clinical Responses in COVID-19 Patients #MMPMID32707096 Wang N; Zhan Y; Zhu L; Hou Z; Liu F; Song P; Qiu F; Wang X; Zou X; Wan D; Qian X; Wang S; Guo Y; Yu H; Cui M; Tong G; Xu Y; Zheng Z; Lu Y; Hong P Cell Host Microbe 2020[Sep]; 28 (3): 455-464.e2 PMID32707096show ga Interferons (IFNs) are widely used in treating coronavirus disease 2019 (COVID-19) patients. However, a recent report of ACE2, the host factor mediating SARS-Cov-2 infection, identifying it as interferon-stimulated raised considerable safety concern. To examine the association between the use and timing of IFN-alpha2b and clinical outcomes, we analyzed in a retrospective multicenter cohort study of 446 COVID-19 patients in Hubei, China. Regression models estimated that early administration ( |*Betacoronavirus[MESH] |Adolescent[MESH] |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Antiviral Agents/*administration & dosage/therapeutic use[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Child[MESH] |China/epidemiology[MESH] |Cohort Studies[MESH] |Coronavirus Infections/*drug therapy/epidemiology/mortality[MESH] |Drug Therapy, Combination[MESH] |Female[MESH] |Hospital Mortality[MESH] |Host Microbial Interactions/drug effects[MESH] |Humans[MESH] |Indoles/administration & dosage[MESH] |Interferon alpha-2[MESH] |Interferon-alpha/administration & dosage/*therapeutic use[MESH] |Length of Stay[MESH] |Lopinavir/administration & dosage[MESH] |Male[MESH] |Middle Aged[MESH] |Pandemics[MESH] |Pneumonia, Viral/*drug therapy/epidemiology/mortality[MESH] |Retrospective Studies[MESH] |Ritonavir/administration & dosage[MESH] |SARS-CoV-2[MESH] |Treatment Outcome[MESH]Retrospective Multicenter Cohort Study Shows Early Interferon Therapy (epmc).pdf DeepDyve Pubget Overpricing