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10.1016/j.chest.2020.07.026 http://scihub22266oqcxt.onion/10.1016/j.chest.2020.07.026 32707180!7373051!32707180     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32707180&cmd=llinks): Failed to open stream: HTTP request failed! 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Characterization of Experimental and Clinical Bioaerosol Generation During Potential Aerosol-Generating Procedures |pdf=|usr=}}{{32707180}} gab.com Text Characterization of Experimental and Clinical Bioaerosol Generation During Potential Aerosol-Generating Procedures JO: Chest http://www.kidney.de/pget.php?&tw=1&pmid=32707180 #FOAvip BACKGROUND: During medical procedures with the potential to produce aerosols such as bronchoscopy, intubation, or CPR, health-care workers (HCWs) may be exposed to infectious bioaerosols. This scenario is of particular concern when high consequence pathogens such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are circulating. Thousands of HCWs have been infected with SARS-CoV-2. However, the determinants of aerosol generation during medical procedures and their relative risk to HCWs remain poorly characterized. RESEARCH QUESTION: The goal of this study was to characterize aerosols produced during airway intubation by using an uninfected translational animal model and in human subjects undergoing elective aerosol-generating procedures. The study also determined the particle size distribution of generated particles. STUDY DESIGN AND METHODS: Aerosol generation was measured during highly controlled experimental (pig) intubations (N = 16) and elective bronchoscopies in uninfected patients (N = 49) using an optical particle counter. Recovery of normal respiratory flora was used as a surrogate for pathogen dispersion. RESULTS: There was a small but significant (P = .03) decrease in 0.3 mum size particles during highly controlled pig intubations compared with baseline. The concentration of 1.0 mum and 5.0 mum aerosol particles did not significantly change, although oral bacteria were collected from the air. For elective patient bronchoscopies, there was a significant decrease in the generation of larger particles (1.0 mum and 5.0 mum) compared with baseline (P < .01); however, 18 of 39 (46%) patients showed increased aerosol production in 0.3 mum size particles, four of whom exhibited measurable increases. INTERPRETATION: Although the total amount of aerosols produced during intubation and bronchoscopy did not increase significantly relative to preprocedural levels, a small number of participants exhibited a measurable increase in submicron particle emission, meriting further research to delineate determinants of fine particle production during aerosol-generating procedures. Twit Text FOAVip Characterization of Experimental and Clinical Bioaerosol Generation During Potential Aerosol-Generating Procedures ????Chest http://www.kidney.de/pget.php?&tw=1&pmid=32707180 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32707180 #FOAvip English Wikipedia <ref>{{Cite pmid|32707180}}</ref> Characterization of Experimental and Clinical Bioaerosol Generation During Potential Aerosol-Generating Procedures #MMPMID32707180 Doggett N; Chow CW; Mubareka S Chest 2020[Dec]; 158 (6): 2467-2473 PMID32707180show ga BACKGROUND: During medical procedures with the potential to produce aerosols such as bronchoscopy, intubation, or CPR, health-care workers (HCWs) may be exposed to infectious bioaerosols. This scenario is of particular concern when high consequence pathogens such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are circulating. Thousands of HCWs have been infected with SARS-CoV-2. However, the determinants of aerosol generation during medical procedures and their relative risk to HCWs remain poorly characterized. RESEARCH QUESTION: The goal of this study was to characterize aerosols produced during airway intubation by using an uninfected translational animal model and in human subjects undergoing elective aerosol-generating procedures. The study also determined the particle size distribution of generated particles. STUDY DESIGN AND METHODS: Aerosol generation was measured during highly controlled experimental (pig) intubations (N = 16) and elective bronchoscopies in uninfected patients (N = 49) using an optical particle counter. Recovery of normal respiratory flora was used as a surrogate for pathogen dispersion. RESULTS: There was a small but significant (P = .03) decrease in 0.3 mum size particles during highly controlled pig intubations compared with baseline. The concentration of 1.0 mum and 5.0 mum aerosol particles did not significantly change, although oral bacteria were collected from the air. For elective patient bronchoscopies, there was a significant decrease in the generation of larger particles (1.0 mum and 5.0 mum) compared with baseline (P < .01); however, 18 of 39 (46%) patients showed increased aerosol production in 0.3 mum size particles, four of whom exhibited measurable increases. INTERPRETATION: Although the total amount of aerosols produced during intubation and bronchoscopy did not increase significantly relative to preprocedural levels, a small number of participants exhibited a measurable increase in submicron particle emission, meriting further research to delineate determinants of fine particle production during aerosol-generating procedures. |*Bronchoscopy[MESH] |*Infectious Disease Transmission, Patient-to-Professional[MESH] |*Intubation, Intratracheal[MESH] |*Particle Size[MESH] |*Particulate Matter[MESH] |Aerosols[MESH] |Animals[MESH] |Biopsy[MESH] |Bronchoalveolar Lavage[MESH] |COVID-19/*transmission[MESH] |Cough[MESH] |Elective Surgical Procedures[MESH] |Health Personnel[MESH] |Humans[MESH] |Microbiota[MESH] |Optical Devices[MESH] |Personal Protective Equipment[MESH] |Respiratory System/microbiology[MESH] |Risk[MESH] |Suction[MESH]Characterization of Experimental and Clinical Bioaerosol Generation Du(epmc).pdf DeepDyve Pubget Overpricing