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10.1007/s00702-020-02230-x http://scihub22266oqcxt.onion/10.1007/s00702-020-02230-x 32725545!7386201!32725545     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32725545&cmd=llinks): Failed to open stream: HTTP request failed! 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Coronaviruses: a challenge of today and a call for extended human postmortem brain analyses |pdf=|usr=}}{{32725545}} gab.com Text Coronaviruses: a challenge of today and a call for extended human postmortem brain analyses JO: J Neural Transm (Vienna) http://www.kidney.de/pget.php?&tw=1&pmid=32725545 #FOAvip While there is abounding literature on virus-induced pathology in general and coronavirus in particular, recent evidence accumulates showing distinct and deleterious brain affection. As the respiratory tract connects to the brain without protection of the blood-brain barrier, SARS-CoV-2 might in the early invasive phase attack the cardiorespiratory centres located in the medulla/pons areas, giving rise to disturbances of respiration and cardiac problems. Furthermore, brainstem regions are at risk to lose their functional integrity. Therefore, long-term neurological as well as psychiatric symptomatology and eventual respective disorders cannot be excluded as evidenced from influenza-A triggered post-encephalitic Parkinsonism and HIV-1 triggered AIDS-dementia complex. From the available evidences for coronavirus-induced brain pathology, this review concludes a number of unmet needs for further research strategies like human postmortem brain analyses. SARS-CoV-2 mirroring experimental animal brain studies, characterization of time-dependent and region-dependent spreading behaviours of coronaviruses, enlightening of pathological mechanisms after coronavirus infection using long-term animal models and clinical observations of patients having had COVID-19 infection are calling to develop both protective strategies and drug discoveries to avoid early and late coronavirus-induced functional brain disturbances, symptoms and eventually disorders. To fight SARS-CoV-2, it is an urgent need to enforce clinical, molecular biological, neurochemical and genetic research including brain-related studies on a worldwide harmonized basis. Twit Text FOAVip Coronaviruses: a challenge of today and a call for extended human postmortem brain analyses ????J Neural Transm (Vienna) http://www.kidney.de/pget.php?&tw=1&pmid=32725545 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32725545 #FOAvip English Wikipedia <ref>{{Cite pmid|32725545}}</ref> Coronaviruses: a challenge of today and a call for extended human postmortem brain analyses #MMPMID32725545 Riederer P; Ter Meulen V J Neural Transm (Vienna) 2020[Sep]; 127 (9): 1217-1228 PMID32725545show ga While there is abounding literature on virus-induced pathology in general and coronavirus in particular, recent evidence accumulates showing distinct and deleterious brain affection. As the respiratory tract connects to the brain without protection of the blood-brain barrier, SARS-CoV-2 might in the early invasive phase attack the cardiorespiratory centres located in the medulla/pons areas, giving rise to disturbances of respiration and cardiac problems. Furthermore, brainstem regions are at risk to lose their functional integrity. Therefore, long-term neurological as well as psychiatric symptomatology and eventual respective disorders cannot be excluded as evidenced from influenza-A triggered post-encephalitic Parkinsonism and HIV-1 triggered AIDS-dementia complex. From the available evidences for coronavirus-induced brain pathology, this review concludes a number of unmet needs for further research strategies like human postmortem brain analyses. SARS-CoV-2 mirroring experimental animal brain studies, characterization of time-dependent and region-dependent spreading behaviours of coronaviruses, enlightening of pathological mechanisms after coronavirus infection using long-term animal models and clinical observations of patients having had COVID-19 infection are calling to develop both protective strategies and drug discoveries to avoid early and late coronavirus-induced functional brain disturbances, symptoms and eventually disorders. To fight SARS-CoV-2, it is an urgent need to enforce clinical, molecular biological, neurochemical and genetic research including brain-related studies on a worldwide harmonized basis. |*Betacoronavirus[MESH] |*Diagnosis[MESH] |Blood-Brain Barrier/pathology/virology[MESH] |Brain/*pathology/virology[MESH] |COVID-19[MESH] |Coronavirus Infections/*pathology[MESH] |Diagnostic Techniques and Procedures/trends[MESH] |Humans[MESH] |Pandemics[MESH] |Pneumonia, Viral/*pathology[MESH] |SARS-CoV-2[MESH]Coronaviruses: a challenge of today and a call for extended human post(epmc).pdf DeepDyve Pubget Overpricing