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10.1084/jem.20201241 http://scihub22266oqcxt.onion/10.1084/jem.20201241 32750141!7401025!32750141     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32750141&cmd=llinks): Failed to open stream: HTTP request failed! 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Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling |pdf=|usr=}}{{32750141}} gab.com Text Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=32750141 #FOAvip Severe acute respiratory syndrome-coronavirus 2 (SARS-Cov-2) has caused over 13,000,000 cases of coronavirus disease (COVID-19) with a significant fatality rate. Laboratory mice have been the stalwart of therapeutic and vaccine development; however, they do not support infection by SARS-CoV-2 due to the virus's inability to use the mouse orthologue of its human entry receptor angiotensin-converting enzyme 2 (hACE2). While hACE2 transgenic mice support infection and pathogenesis, these mice are currently limited in availability and are restricted to a single genetic background. Here we report the development of a mouse model of SARS-CoV-2 based on adeno-associated virus (AAV)-mediated expression of hACE2. These mice support viral replication and exhibit pathological findings found in COVID-19 patients. Moreover, we show that type I interferons do not control SARS-CoV-2 replication in vivo but are significant drivers of pathological responses. Thus, the AAV-hACE2 mouse model enables rapid deployment for in-depth analysis following robust SARS-CoV-2 infection with authentic patient-derived virus in mice of diverse genetic backgrounds. Twit Text FOAVip Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=32750141 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32750141 #FOAvip English Wikipedia <ref>{{Cite pmid|32750141}}</ref> Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling #MMPMID32750141 Israelow B; Song E; Mao T; Lu P; Meir A; Liu F; Alfajaro MM; Wei J; Dong H; Homer RJ; Ring A; Wilen CB; Iwasaki A J Exp Med 2020[Dec]; 217 (12): ä PMID32750141show ga Severe acute respiratory syndrome-coronavirus 2 (SARS-Cov-2) has caused over 13,000,000 cases of coronavirus disease (COVID-19) with a significant fatality rate. Laboratory mice have been the stalwart of therapeutic and vaccine development; however, they do not support infection by SARS-CoV-2 due to the virus's inability to use the mouse orthologue of its human entry receptor angiotensin-converting enzyme 2 (hACE2). While hACE2 transgenic mice support infection and pathogenesis, these mice are currently limited in availability and are restricted to a single genetic background. Here we report the development of a mouse model of SARS-CoV-2 based on adeno-associated virus (AAV)-mediated expression of hACE2. These mice support viral replication and exhibit pathological findings found in COVID-19 patients. Moreover, we show that type I interferons do not control SARS-CoV-2 replication in vivo but are significant drivers of pathological responses. Thus, the AAV-hACE2 mouse model enables rapid deployment for in-depth analysis following robust SARS-CoV-2 infection with authentic patient-derived virus in mice of diverse genetic backgrounds. |*Disease Models, Animal[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Animals[MESH] |Betacoronavirus/*metabolism[MESH] |COVID-19[MESH] |Cell Line, Tumor[MESH] |Coronavirus Infections/*metabolism/pathology/virology[MESH] |Dependovirus/genetics[MESH] |Female[MESH] |Humans[MESH] |Inflammation/metabolism[MESH] |Interferon Type I/*metabolism[MESH] |Lung/pathology/virology[MESH] |Male[MESH] |Mice, Inbred C57BL[MESH] |Mice, Transgenic[MESH] |Mice/*genetics[MESH] |Pandemics[MESH] |Parvoviridae Infections/metabolism/virology[MESH] |Peptidyl-Dipeptidase A/genetics/*metabolism[MESH] |Pneumonia, Viral/*metabolism/pathology/virology[MESH] |SARS-CoV-2[MESH] |Signal Transduction/genetics[MESH]Mouse model of SARS-CoV-2 reveals inflammatory role of type I interfer(epmc).pdf DeepDyve Pubget Overpricing