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10.7554/eLife.57132 http://scihub22266oqcxt.onion/10.7554/eLife.57132 32876563!7467724!32876563     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 300.79999999999995 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\32876563.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Elife 2020 ; 9 (ä): ä Nephropedia Template TP {{tp|p=32876563|t=2020. CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance |pdf=|usr=}}{{32876563}} gab.com Text CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance JO: Elife http://www.kidney.de/pget.php?&tw=1&pmid=32876563 #FOAvip Porcine reproductive and respiratory syndrome virus (PRRSV) and transmissible gastroenteritis virus (TGEV) are two highly infectious and lethal viruses causing major economic losses to pig production. Here, we report generation of double-gene-knockout (DKO) pigs harboring edited knockout alleles for known receptor proteins CD163 and pAPN and show that DKO pigs are completely resistant to genotype 2 PRRSV and TGEV. We found no differences in meat-production or reproductive-performance traits between wild-type and DKO pigs, but detected increased iron in DKO muscle. Additional infection challenge experiments showed that DKO pigs exhibited decreased susceptibility to porcine deltacoronavirus (PDCoV), thus offering unprecedented in vivo evidence of pAPN as one of PDCoV receptors. Beyond showing that multiple gene edits can be combined in a livestock animal to achieve simultaneous resistance to two major viruses, our study introduces a valuable model for investigating infection mechanisms of porcine pathogenic viruses that exploit pAPN or CD163 for entry. Twit Text FOAVip CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance ????Elife http://www.kidney.de/pget.php?&tw=1&pmid=32876563 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32876563 #FOAvip English Wikipedia <ref>{{Cite pmid|32876563}}</ref> CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV and exhibit decreased susceptibility to PDCoV while maintaining normal production performance #MMPMID32876563 Xu K; Zhou Y; Mu Y; Liu Z; Hou S; Xiong Y; Fang L; Ge C; Wei Y; Zhang X; Xu C; Che J; Fan Z; Xiang G; Guo J; Shang H; Li H; Xiao S; Li J; Li K Elife 2020[Sep]; 9 (ä): ä PMID32876563show ga Porcine reproductive and respiratory syndrome virus (PRRSV) and transmissible gastroenteritis virus (TGEV) are two highly infectious and lethal viruses causing major economic losses to pig production. Here, we report generation of double-gene-knockout (DKO) pigs harboring edited knockout alleles for known receptor proteins CD163 and pAPN and show that DKO pigs are completely resistant to genotype 2 PRRSV and TGEV. We found no differences in meat-production or reproductive-performance traits between wild-type and DKO pigs, but detected increased iron in DKO muscle. Additional infection challenge experiments showed that DKO pigs exhibited decreased susceptibility to porcine deltacoronavirus (PDCoV), thus offering unprecedented in vivo evidence of pAPN as one of PDCoV receptors. Beyond showing that multiple gene edits can be combined in a livestock animal to achieve simultaneous resistance to two major viruses, our study introduces a valuable model for investigating infection mechanisms of porcine pathogenic viruses that exploit pAPN or CD163 for entry. |Animals[MESH] |Animals, Genetically Modified[MESH] |Antigens, CD/genetics/immunology[MESH] |Antigens, Differentiation, Myelomonocytic/genetics/immunology[MESH] |Body Composition[MESH] |CD13 Antigens/*deficiency/genetics/immunology[MESH] |CD163 Antigen[MESH] |Coronavirus Infections/genetics/immunology/*prevention & control/virology[MESH] |Coronavirus/immunology/*pathogenicity[MESH] |Disease Susceptibility[MESH] |Gastroenteritis, Transmissible, of Swine/genetics/immunology/*prevention & control/virology[MESH] |Gene Knockdown Techniques[MESH] |Host Microbial Interactions[MESH] |Meat-Packing Industry[MESH] |Phenotype[MESH] |Porcine Reproductive and Respiratory Syndrome/genetics/immunology/*prevention & control/virology[MESH] |Porcine respiratory and reproductive syndrome virus/immunology/*pathogenicity[MESH] |Receptors, Cell Surface/*deficiency/genetics/immunology[MESH] |Sus scrofa/genetics[MESH] |Swine[MESH] |Transmissible gastroenteritis virus/immunology/*pathogenicity[MESH]CD163 and pAPN double-knockout pigs are resistant to PRRSV and TGEV an(epmc).pdf DeepDyve Pubget Overpricing