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10.1111/ceo.13855 http://scihub22266oqcxt.onion/10.1111/ceo.13855 32902023!ä!32902023 Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32902023&cmd=llinks): Failed to open stream: HTTP request failed! 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Proof-of-concept calculations to determine the health-adjusted life-year trade-off between intravitreal anti-VEGF injections and transmission of COVID-19 |pdf=|usr=}}{{32902023}} gab.com Text Proof-of-concept calculations to determine the health-adjusted life-year trade-off between intravitreal anti-VEGF injections and transmission of COVID-19 JO: Clin Exp Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=32902023 #FOAvip BACKGROUND: Clinical ophthalmological guidelines encourage the assessment of potential benefits and harms when deciding whether to perform elective ophthalmology procedures during the COVID-19 pandemic, in order to minimize the risk of disease transmission. METHOD: We performed probability calculations to estimate COVID-19 infection status and likelihood of disease transmission among neovascular age-related macular degeneration patients and health-care workers during anti-VEGF procedures, at various community prevalence levels of COVID-19. We then applied the expected burden of COVID-19 illness and death expressed through health-adjusted life-years (HALYs) lost. We compared these results to the expected disease burden of severe visual impairment if sight protecting anti-VEGF injections were not performed. RESULTS: Our calculations suggest a wide range of contexts where the benefits of treatment to prevent progression to severe visual impairment or blindness are greater than the expected harms to the patient and immediate health care team due to COVID-19. For example, with appropriate protective equipment the benefits of treatment outweigh harms when the chance of progression to severe visual impairment is >0.044% for all scenarios where COVID-19 prevalence was 1/1000, even when the attack rate in the clinical setting is very high (5-43%). CONCLUSION: Unless COVID-19 prevalence is very high, the reduced disease burden from avoiding visual impairment outweighs the expected HALYs lost from COVID-19 transmission. This finding is driven by the fact that HALYs lost when someone suffers severe visual impairment for 5 years are equivalent to nearly 400 moderate cases of infectious disease lasting 2 weeks each. Twit Text FOAVip Proof-of-concept calculations to determine the health-adjusted life-year trade-off between intravitreal anti-VEGF injections and transmission of COVID-19 ????Clin Exp Ophthalmol http://www.kidney.de/pget.php?&tw=1&pmid=32902023 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=32902023 #FOAvip English Wikipedia <ref>{{Cite pmid|32902023}}</ref> Proof-of-concept calculations to determine the health-adjusted life-year trade-off between intravitreal anti-VEGF injections and transmission of COVID-19 #MMPMID32902023 Boyd MJ; Scott DAR; Squirrell DM; Wilson GA Clin Exp Ophthalmol 2020[Dec]; 48 (9): 1276-1285 PMID32902023show ga BACKGROUND: Clinical ophthalmological guidelines encourage the assessment of potential benefits and harms when deciding whether to perform elective ophthalmology procedures during the COVID-19 pandemic, in order to minimize the risk of disease transmission. METHOD: We performed probability calculations to estimate COVID-19 infection status and likelihood of disease transmission among neovascular age-related macular degeneration patients and health-care workers during anti-VEGF procedures, at various community prevalence levels of COVID-19. We then applied the expected burden of COVID-19 illness and death expressed through health-adjusted life-years (HALYs) lost. We compared these results to the expected disease burden of severe visual impairment if sight protecting anti-VEGF injections were not performed. RESULTS: Our calculations suggest a wide range of contexts where the benefits of treatment to prevent progression to severe visual impairment or blindness are greater than the expected harms to the patient and immediate health care team due to COVID-19. For example, with appropriate protective equipment the benefits of treatment outweigh harms when the chance of progression to severe visual impairment is >0.044% for all scenarios where COVID-19 prevalence was 1/1000, even when the attack rate in the clinical setting is very high (5-43%). CONCLUSION: Unless COVID-19 prevalence is very high, the reduced disease burden from avoiding visual impairment outweighs the expected HALYs lost from COVID-19 transmission. This finding is driven by the fact that HALYs lost when someone suffers severe visual impairment for 5 years are equivalent to nearly 400 moderate cases of infectious disease lasting 2 weeks each. |*Pandemics[MESH] |*SARS-CoV-2[MESH] |*Visual Acuity[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Angiogenesis Inhibitors/administration & dosage/*adverse effects[MESH] |COVID-19/epidemiology/*transmission[MESH] |Comorbidity[MESH] |Disease Transmission, Infectious/*statistics & numerical data[MESH] |Female[MESH] |Humans[MESH] |Intravitreal Injections/adverse effects[MESH] |Macular Degeneration/*drug therapy/epidemiology[MESH] |Male[MESH] |Middle Aged[MESH]Proof-of-concept calculations to determine the health-adjusted life-ye(epmc).pdf DeepDyve Pubget Overpricing