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10.1111/jch.14011

http://scihub22266oqcxt.onion/10.1111/jch.14011
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32937008!7722152!32937008
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suck abstract from ncbi


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pmid32937008      J+Clin+Hypertens+(Greenwich) 2020 ; 22 (10): 1780-1788
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  • Randomized elimination and prolongation of ACE inhibitors and ARBs in coronavirus 2019 (REPLACE COVID) Trial Protocol #MMPMID32937008
  • Cohen JB; Hanff TC; Corrales-Medina V; William P; Renna N; Rosado-Santander NR; Rodriguez-Mori JE; Spaak J; Andrade-Villanueva J; Chang TI; Barbagelata A; Alfonso CE; Bernales-Salas E; Coacalla J; Castro-Callirgos CA; Tupayachi-Venero KE; Medina C; Valdivia R; Villavicencio M; Vasquez CR; Harhay MO; Chittams J; Sharkoski T; Byrd JB; Edmonston DL; Sweitzer N; Chirinos JA
  • J Clin Hypertens (Greenwich) 2020[Oct]; 22 (10): 1780-1788 PMID32937008show ga
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), is associated with high incidence of multiorgan dysfunction and death. Angiotensin-converting enzyme 2 (ACE2), which facilitates SARS-CoV-2 host cell entry, may be impacted by angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), two commonly used antihypertensive classes. In a multicenter, international randomized controlled trial that began enrollment on March 31, 2020, participants are randomized to continuation vs withdrawal of their long-term outpatient ACEI or ARB upon hospitalization with COVID-19. The primary outcome is a hierarchical global rank score incorporating time to death, duration of mechanical ventilation, duration of renal replacement or vasopressor therapy, and multiorgan dysfunction severity. Approval for the study has been obtained from the Institutional Review Board of each participating institution, and all participants will provide informed consent. A data safety monitoring board has been assembled to provide independent oversight of the project.
  • |Adult[MESH]
  • |Angiotensin Receptor Antagonists/adverse effects/*pharmacology[MESH]
  • |Angiotensin-Converting Enzyme Inhibitors/adverse effects/*pharmacology[MESH]
  • |COVID-19/*complications/epidemiology/virology[MESH]
  • |Case-Control Studies[MESH]
  • |Female[MESH]
  • |Hospitalization/statistics & numerical data[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Male[MESH]
  • |Multiple Organ Failure/*epidemiology/mortality[MESH]
  • |Prospective Studies[MESH]
  • |Renal Replacement Therapy/statistics & numerical data[MESH]
  • |Respiration, Artificial/statistics & numerical data[MESH]
  • |SARS-CoV-2/*drug effects/genetics[MESH]
  • |Severity of Illness Index[MESH]
  • |Vasoconstrictor Agents/therapeutic use[MESH]


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