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Recent endemic coronavirus infection is associated with less-severe COVID-19 #MMPMID32997649
Sagar M; Reifler K; Rossi M; Miller NS; Sinha P; White LF; Mizgerd JP
J Clin Invest 2021[Jan]; 131 (1): ä PMID32997649show ga
Four different endemic coronaviruses (eCoVs) are etiologic agents for the seasonal common cold, and these eCoVs share extensive sequence homology with human SARS coronavirus 2 (SARS-CoV-2). Here, we show that individuals with, as compared with those without, a recent documented infection with eCoV were tested at greater frequency for respiratory infections but had a similar rate of SARS-CoV-2 acquisition. Importantly, the patients with a previously detected eCoV had less-severe coronavirus disease 2019 (COVID-19) illness. Our observations suggest that preexisting immune responses against endemic human coronaviruses can mitigate disease manifestations from SARS-CoV-2 infection.