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10.1016/j.bbrc.2020.09.042 http://scihub22266oqcxt.onion/10.1016/j.bbrc.2020.09.042 33008593!7489930!33008593     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33008593&cmd=llinks): Failed to open stream: HTTP request failed! 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The expression of SARS-CoV-2 receptor ACE2 and CD147, and protease TMPRSS2 in human and mouse brain cells and mouse brain tissues |pdf=|usr=}}{{33008593}} gab.com Text The expression of SARS-CoV-2 receptor ACE2 and CD147, and protease TMPRSS2 in human and mouse brain cells and mouse brain tissues JO: Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=33008593 #FOAvip Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been discovered as the pathogenic cause of the coronavirus disease 19 (COVID-19). Cellular entry of SARS-CoV-2 are mediated by the spike glycoprotein of virus, and the host specific receptors and proteases. Recently, besides pulmonary complications as the chief symptom, investigations have also revealed that SARS-CoV-2 can trigger neurological manifestations. Herein, to investigate the expression level of receptors and related proteases is important for understanding the neuropathy in COVID-19. We determined the expression levels of receptor ACE2 and CD147, and serine protease TMPRSS2 in human and mouse brain cell lines and mouse different region of brain tissues with qRT-PCR and Western blot. The results showed that the expression pattern of all them was very different to that of lung. ACE2 is lower but CD147 is higher expressed in mostly brain cell lines and mouse brain tissues comparing with lung cell line and tissue, and TMPRSS2 has consistent expression in brain cell lines and mouse lung tissues. It is suggested that SARS-CoV-2 might have a different way of infection to cerebral nervous system. Our finding will offer the clues to predict the possibility of SARS-CoV-2 infection to human brain nervous system and pathogenicity. Twit Text FOAVip The expression of SARS-CoV-2 receptor ACE2 and CD147, and protease TMPRSS2 in human and mouse brain cells and mouse brain tissues ????Biochem Biophys Res Commun http://www.kidney.de/pget.php?&tw=1&pmid=33008593 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33008593 #FOAvip English Wikipedia <ref>{{Cite pmid|33008593}}</ref> The expression of SARS-CoV-2 receptor ACE2 and CD147, and protease TMPRSS2 in human and mouse brain cells and mouse brain tissues #MMPMID33008593 Qiao J; Li W; Bao J; Peng Q; Wen D; Wang J; Sun B Biochem Biophys Res Commun 2020[Dec]; 533 (4): 867-871 PMID33008593show ga Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been discovered as the pathogenic cause of the coronavirus disease 19 (COVID-19). Cellular entry of SARS-CoV-2 are mediated by the spike glycoprotein of virus, and the host specific receptors and proteases. Recently, besides pulmonary complications as the chief symptom, investigations have also revealed that SARS-CoV-2 can trigger neurological manifestations. Herein, to investigate the expression level of receptors and related proteases is important for understanding the neuropathy in COVID-19. We determined the expression levels of receptor ACE2 and CD147, and serine protease TMPRSS2 in human and mouse brain cell lines and mouse different region of brain tissues with qRT-PCR and Western blot. The results showed that the expression pattern of all them was very different to that of lung. ACE2 is lower but CD147 is higher expressed in mostly brain cell lines and mouse brain tissues comparing with lung cell line and tissue, and TMPRSS2 has consistent expression in brain cell lines and mouse lung tissues. It is suggested that SARS-CoV-2 might have a different way of infection to cerebral nervous system. Our finding will offer the clues to predict the possibility of SARS-CoV-2 infection to human brain nervous system and pathogenicity. |Angiotensin-Converting Enzyme 2/genetics/*metabolism[MESH] |Animals[MESH] |Basigin/genetics/*metabolism[MESH] |Brain/*cytology/*metabolism[MESH] |Cell Line[MESH] |Humans[MESH] |Mice[MESH] |RNA, Messenger/genetics/metabolism[MESH] |Receptors, Coronavirus/genetics/*metabolism[MESH] |SARS-CoV-2/*metabolism[MESH]The expression of SARS-CoV-2 receptor ACE2 and CD147, and protease TMP(epmc).pdf DeepDyve Pubget Overpricing