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10.2991/jegh.k.200729.001 http://scihub22266oqcxt.onion/10.2991/jegh.k.200729.001 33009729!7958277!33009729     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33009729&cmd=llinks): Failed to open stream: HTTP request failed! 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Pride and Prejudice during the COVID-19 Pandemic: The Misfortune of Inappropriate Clinical Trial Design |pdf=|usr=}}{{33009729}} gab.com Text Pride and Prejudice during the COVID-19 Pandemic: The Misfortune of Inappropriate Clinical Trial Design JO: J Epidemiol Glob Health http://www.kidney.de/pget.php?&tw=1&pmid=33009729 #FOAvip Coronavirus Disease 2019 (COVID-19) is a rapidly evolving global pandemic for which more than a thousand clinical trials have been registered to secure therapeutic effectiveness, expeditiously. Most of these are single-center non-randomized studies rather than multi-center, randomized controlled trials. Single-arm trials have several limitations and may be conducted when spontaneous improvement is not anticipated, small placebo effect exists, and randomization to a placebo is not ethical. In an emergency where saving lives takes precedence, it is ethical to conduct trials with any scientifically proven design, however, safety must not be compromised. A phase II or III trial can be conducted directly in a pandemic with appropriate checkpoints and stopping rules. COVID-19 has two management paradigms- antivirals, or treatment of its complications. Simultaneous assessment of two different treatments can be done using 2 x 2 factorial schema. World Health Organization's SOLIDARITY trial is a classic example of the global research protocol which can evaluate the preferred treatment to combat COVID-19 pandemic. Short of that, a trial design must incorporate the practicality of the intervention used, and an appropriate primary endpoint which should ideally be a clinical outcome. Collaboration between institutions is needed more than ever to successfully execute and accrue in randomized trials. Twit Text FOAVip Pride and Prejudice during the COVID-19 Pandemic: The Misfortune of Inappropriate Clinical Trial Design ????J Epidemiol Glob Health http://www.kidney.de/pget.php?&tw=1&pmid=33009729 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33009729 #FOAvip English Wikipedia <ref>{{Cite pmid|33009729}}</ref> Pride and Prejudice during the COVID-19 Pandemic: The Misfortune of Inappropriate Clinical Trial Design #MMPMID33009729 Hashmi SK; De Vol E; Hussain F J Epidemiol Glob Health 2021[Mar]; 11 (1): 15-19 PMID33009729show ga Coronavirus Disease 2019 (COVID-19) is a rapidly evolving global pandemic for which more than a thousand clinical trials have been registered to secure therapeutic effectiveness, expeditiously. Most of these are single-center non-randomized studies rather than multi-center, randomized controlled trials. Single-arm trials have several limitations and may be conducted when spontaneous improvement is not anticipated, small placebo effect exists, and randomization to a placebo is not ethical. In an emergency where saving lives takes precedence, it is ethical to conduct trials with any scientifically proven design, however, safety must not be compromised. A phase II or III trial can be conducted directly in a pandemic with appropriate checkpoints and stopping rules. COVID-19 has two management paradigms- antivirals, or treatment of its complications. Simultaneous assessment of two different treatments can be done using 2 x 2 factorial schema. World Health Organization's SOLIDARITY trial is a classic example of the global research protocol which can evaluate the preferred treatment to combat COVID-19 pandemic. Short of that, a trial design must incorporate the practicality of the intervention used, and an appropriate primary endpoint which should ideally be a clinical outcome. Collaboration between institutions is needed more than ever to successfully execute and accrue in randomized trials. |*COVID-19 Drug Treatment[MESH] |*Information Dissemination/ethics/methods[MESH] |*Non-Randomized Controlled Trials as Topic/ethics/methods/standards[MESH] |*Research Design/standards/trends[MESH] |*Safety Management/ethics/standards[MESH] |COVID-19/epidemiology[MESH] |Early Termination of Clinical Trials/methods[MESH] |Ethics[MESH] |Humans[MESH]Pride and Prejudice during the COVID-19 Pandemic: The Misfortune of In(epmc).pdf DeepDyve Pubget Overpricing