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10.1016/j.ejphar.2020.173615 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2020.173615 33011243!7527794!33011243     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33011243&cmd=llinks): Failed to open stream: HTTP request failed! 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New putative insights into neprilysin (NEP)-dependent pharmacotherapeutic role of roflumilast in treating COVID-19 |pdf=|usr=}}{{33011243}} gab.com Text New putative insights into neprilysin (NEP)-dependent pharmacotherapeutic role of roflumilast in treating COVID-19 JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33011243 #FOAvip Nowadays, coronavirus disease 2019 (COVID-19) represents the most serious inflammatory respiratory disease worldwide. Despite many proposed therapies, no effective medication has yet been approved. Neutrophils appear to be the key mediator for COVID-19-associated inflammatory immunopathologic, thromboembolic and fibrotic complications. Thus, for any therapeutic agent to be effective, it should greatly block the neutrophilic component of COVID-19. One of the effective therapeutic approaches investigated to reduce neutrophil-associated inflammatory lung diseases with few adverse effects was roflumilast. Being a highly selective phosphodiesterase-4 inhibitors (PDE4i), roflumilast acts by enhancing the level of cyclic adenosine monophosphate (cAMP), that probably potentiates its anti-inflammatory action via increasing neprilysin (NEP) activity. Because activating NEP was previously reported to mitigate several airway inflammatory ailments; this review thoroughly discusses the proposed NEP-based therapeutic properties of roflumilast, which may be of great importance in curing COVID-19. However, further clinical studies are required to confirm this strategy and to evaluate its in vivo preventive and therapeutic efficacy against COVID-19. Twit Text FOAVip New putative insights into neprilysin (NEP)-dependent pharmacotherapeutic role of roflumilast in treating COVID-19 ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=33011243 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33011243 #FOAvip English Wikipedia <ref>{{Cite pmid|33011243}}</ref> New putative insights into neprilysin (NEP)-dependent pharmacotherapeutic role of roflumilast in treating COVID-19 #MMPMID33011243 El Tabaa MM; El Tabaa MM Eur J Pharmacol 2020[Dec]; 889 (�): 173615 PMID33011243show ga Nowadays, coronavirus disease 2019 (COVID-19) represents the most serious inflammatory respiratory disease worldwide. Despite many proposed therapies, no effective medication has yet been approved. Neutrophils appear to be the key mediator for COVID-19-associated inflammatory immunopathologic, thromboembolic and fibrotic complications. Thus, for any therapeutic agent to be effective, it should greatly block the neutrophilic component of COVID-19. One of the effective therapeutic approaches investigated to reduce neutrophil-associated inflammatory lung diseases with few adverse effects was roflumilast. Being a highly selective phosphodiesterase-4 inhibitors (PDE4i), roflumilast acts by enhancing the level of cyclic adenosine monophosphate (cAMP), that probably potentiates its anti-inflammatory action via increasing neprilysin (NEP) activity. Because activating NEP was previously reported to mitigate several airway inflammatory ailments; this review thoroughly discusses the proposed NEP-based therapeutic properties of roflumilast, which may be of great importance in curing COVID-19. However, further clinical studies are required to confirm this strategy and to evaluate its in vivo preventive and therapeutic efficacy against COVID-19. |*COVID-19 Drug Treatment[MESH] |Aminopyridines/*pharmacology/*therapeutic use[MESH] |Benzamides/*pharmacology/*therapeutic use[MESH] |Cyclopropanes/pharmacology/therapeutic use[MESH] |Humans[MESH] |Neprilysin/*drug effects[MESH] |Pandemics[MESH]New putative insights into neprilysin (NEP)-dependent pharmacotherapeu(epmc).pdf DeepDyve Pubget Overpricing