
| 10.1093/infdis/jiaa626
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J+Infect+Dis 2021 ; 223 (11): 1879-1886 Nephropedia Template TP
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Comparing Clinical Characteristics of Influenza and Common Coronavirus Infections Using Electronic Health Records #MMPMID33011809Li D; Wolk DM; Cantor MNJ Infect Dis 2021[Jun]; 223 (11): 1879-1886 PMID33011809show ga
BACKGROUND: We compared outcomes in inpatients and outpatients, pre-COVID-19, who were infected with either coronavirus or influenza. METHODS: Using deidentified electronic health records data from the Geisinger-Regeneron partnership, we compared patients with RT-PCR-positive tests for the 4 common coronaviruses (229E, HKU1, NL63, OC43) or influenza (A and B) from June 2016 to February 2019. RESULTS: Overall, 52 833 patients were tested for coronaviruses and influenza. For patients >/=21 years old, 1555 and 3991 patient encounters had confirmed positive coronavirus and influenza tests, respectively. Both groups had similar intensive care unit (ICU) admission rates (7.2% vs 6.1%, P = .12), although patients with coronavirus had significantly more pneumonia (15% vs 7.4%, P < .001) and higher death rate within 30 days (4.9% vs 3.0%, P < .001). After controlling for other covariates, coronavirus infection still had a higher risk of death and pneumonia than influenza (odds ratio, 1.64 and 2.05, P < .001), with no significant difference in ICU admission rates. CONCLUSIONS: Common coronaviruses cause significant morbidity, with potentially worse outcomes than influenza. Identifying a subset of patients who are more susceptible to poor outcomes from common coronavirus infections may help plan clinical interventions in patients with suspected infections.|*Electronic Health Records/statistics & numerical data[MESH]|Adult[MESH]|Age Factors[MESH]|Aged[MESH]|Coronavirus Infections/mortality/*pathology[MESH]|Hospitalization/statistics & numerical data[MESH]|Humans[MESH]|Influenza, Human/mortality/*pathology[MESH]|Intensive Care Units/statistics & numerical data[MESH]|Middle Aged[MESH]|Retrospective Studies[MESH]
  
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