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10.1093/jnci/djaa159

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suck abstract from ncbi


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pmid33031532      J+Natl+Cancer+Inst 2021 ; 113 (6): 691-698
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  • Prevalence and Outcome of COVID-19 Infection in Cancer Patients: A National Veterans Affairs Study #MMPMID33031532
  • Fillmore NR; La J; Szalat RE; Tuck DP; Nguyen V; Yildirim C; Do NV; Brophy MT; Munshi NC
  • J Natl Cancer Inst 2021[Jun]; 113 (6): 691-698 PMID33031532show ga
  • BACKGROUND: Emerging data suggest variability in susceptibility and outcome to coronavirus disease 2019 (COVID-19) infection. Identifying risk factors associated with infection and outcomes in cancer patients is necessary to develop healthcare recommendations. METHODS: We analyzed electronic health records of the US Veterans Affairs Healthcare System and assessed the prevalence of COVID-19 infection in cancer patients. We evaluated the proportion of cancer patients tested for COVID-19 who were positive, as well as outcome attributable to COVID-19, and stratified by clinical characteristics including demographics, comorbidities, cancer treatment, and cancer type. All statistical tests are 2-sided. RESULTS: Of 22 914 cancer patients tested for COVID-19, 1794 (7.8%) were positive. The prevalence of COVID-19 was similar across age. Higher prevalence was observed in African American (15.0%) compared with White (5.5%; P < .001) and in patients with hematologic malignancy compared with those with solid tumors (10.9% vs 7.8%; P < .001). Conversely, prevalence was lower in current smokers and patients who recently received cancer therapy (<6 months). The COVID-19-attributable mortality was 10.9%. Higher attributable mortality rates were observed in older patients, those with higher Charlson comorbidity score, and in certain cancer types. Recent (<6 months) or past treatment did not influence attributable mortality. Importantly, African American patients had 3.5-fold higher COVID-19-attributable hospitalization; however, they had similar attributable mortality as White patients. CONCLUSION: Preexistence of cancer affects both susceptibility to COVID-19 infection and eventual outcome. The overall COVID-19-attributable mortality in cancer patients is affected by age, comorbidity, and specific cancer types; however, race or recent treatment including immunotherapy do not impact outcome.
  • |COVID-19/*epidemiology[MESH]
  • |Humans[MESH]
  • |Neoplasms/*complications[MESH]
  • |Prevalence[MESH]
  • |Risk Factors[MESH]
  • |United States[MESH]


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