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10.1016/j.pneurobio.2020.101919 http://scihub22266oqcxt.onion/10.1016/j.pneurobio.2020.101919 33039415!7543790!33039415     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33039415&cmd=llinks): Failed to open stream: HTTP request failed! 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The intracellular renin-angiotensin system: Friend or foe Some light from the dopaminergic neurons |pdf=|usr=}}{{33039415}} gab.com Text The intracellular renin-angiotensin system: Friend or foe Some light from the dopaminergic neurons JO: Prog Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=33039415 #FOAvip The renin-angiotensin system (RAS) is one of the oldest hormone systems in vertebrate phylogeny. RAS was initially related to regulation of blood pressure and sodium and water homeostasis. However, local or paracrine RAS were later identified in many tissues, including brain, and play a major role in their physiology and pathophysiology. In addition, a major component, ACE2, is the entry receptor for SARS-CoV-2. Overactivation of tissue RAS leads several oxidative stress and inflammatory processes involved in aging-related degenerative changes. In addition, a third level of RAS, the intracellular or intracrine RAS (iRAS), with still unclear functions, has been observed. The possible interaction between the intracellular and extracellular RAS, and particularly the possible deleterious or beneficial effects of the iRAS activation are controversial. The dopaminergic system is particularly interesting to investigate the RAS as important functional interactions between dopamine and RAS have been observed in the brain and several peripheral tissues. Our recent observations in mitochondria and nucleus of dopaminergic neurons may clarify the role of the iRAS. This may be important for the developing of new therapeutic strategies, since the effects on both extracellular and intracellular RAS must be taken into account, and perhaps better understanding of COVID-19 cell mechanisms. Twit Text FOAVip The intracellular renin-angiotensin system: Friend or foe Some light from the dopaminergic neurons ????Prog Neurobiol http://www.kidney.de/pget.php?&tw=1&pmid=33039415 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33039415 #FOAvip English Wikipedia <ref>{{Cite pmid|33039415}}</ref> The intracellular renin-angiotensin system: Friend or foe Some light from the dopaminergic neurons #MMPMID33039415 Labandeira-Garcia JL; Valenzuela R; Costa-Besada MA; Villar-Cheda B; Rodriguez-Perez AI Prog Neurobiol 2021[Apr]; 199 (�): 101919 PMID33039415show ga The renin-angiotensin system (RAS) is one of the oldest hormone systems in vertebrate phylogeny. RAS was initially related to regulation of blood pressure and sodium and water homeostasis. However, local or paracrine RAS were later identified in many tissues, including brain, and play a major role in their physiology and pathophysiology. In addition, a major component, ACE2, is the entry receptor for SARS-CoV-2. Overactivation of tissue RAS leads several oxidative stress and inflammatory processes involved in aging-related degenerative changes. In addition, a third level of RAS, the intracellular or intracrine RAS (iRAS), with still unclear functions, has been observed. The possible interaction between the intracellular and extracellular RAS, and particularly the possible deleterious or beneficial effects of the iRAS activation are controversial. The dopaminergic system is particularly interesting to investigate the RAS as important functional interactions between dopamine and RAS have been observed in the brain and several peripheral tissues. Our recent observations in mitochondria and nucleus of dopaminergic neurons may clarify the role of the iRAS. This may be important for the developing of new therapeutic strategies, since the effects on both extracellular and intracellular RAS must be taken into account, and perhaps better understanding of COVID-19 cell mechanisms. |*Renin-Angiotensin System[MESH] |Animals[MESH] |COVID-19[MESH] |Dopaminergic Neurons/*metabolism[MESH] |Humans[MESH] |Intracellular Space/metabolism[MESH] |Oxidative Stress[MESH]The intracellular renin-angiotensin system: Friend or foe Some light (epmc).pdf DeepDyve Pubget Overpricing