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10.5935/0103-507X.20200063 http://scihub22266oqcxt.onion/10.5935/0103-507X.20200063 33053024!7595716!33053024     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33053024&cmd=llinks): Failed to open stream: HTTP request failed! 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Sindrome do desconforto respiratorio agudo associada a COVID-19 tratada com DEXametasona (CoDEX): delineamento e justificativa de um estudo randomizado |pdf=|usr=}}{{33053024}} gab.com Text Sindrome do desconforto respiratorio agudo associada a COVID-19 tratada com DEXametasona (CoDEX): delineamento e justificativa de um estudo randomizado JO: Rev Bras Ter Intensiva http://www.kidney.de/pget.php?&tw=1&pmid=33053024 #FOAvip OBJECTIVE: The infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads worldwide and is considered a pandemic. The most common manifestation of SARS-CoV-2 infection (coronavirus disease 2019 - COVID-19) is viral pneumonia with varying degrees of respiratory compromise and up to 40% of hospitalized patients might develop acute respiratory distress syndrome. Several clinical trials evaluated the role of corticosteroids in non-COVID-19 acute respiratory distress syndrome with conflicting results. We designed a trial to evaluate the effectiveness of early intravenous dexamethasone administration on the number of days alive and free of mechanical ventilation within 28 days after randomization in adult patients with moderate or severe acute respiratory distress syndrome due to confirmed or probable COVID-19. METHODS: This is a pragmatic, prospective, randomized, stratified, multicenter, open-label, controlled trial including 350 patients with early-onset (less than 48 hours before randomization) moderate or severe acute respiratory distress syndrome, defined by the Berlin criteria, due to COVID-19. Eligible patients will be randomly allocated to either standard treatment plus dexamethasone (Intervention Group) or standard treatment without dexamethasone (Control Group). Patients in the intervention group will receive dexamethasone 20mg intravenous once daily for 5 days, followed by dexamethasone 10mg IV once daily for additional 5 days or until intensive care unit discharge, whichever occurs first. The primary outcome is ventilator-free days within 28 days after randomization, defined as days alive and free from invasive mechanical ventilation. Secondary outcomes are all-cause mortality rates at day 28, evaluation of the clinical status at day 15 assessed with a 6-level ordinal scale, mechanical ventilation duration from randomization to day 28, Sequential Organ Failure Assessment Score evaluation at 48 hours, 72 hours and 7 days and intensive care unit -free days within 28. Twit Text FOAVip Sindrome do desconforto respiratorio agudo associada a COVID-19 tratada com DEXametasona (CoDEX): delineamento e justificativa de um estudo randomizado ????Rev Bras Ter Intensiva http://www.kidney.de/pget.php?&tw=1&pmid=33053024 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33053024 #FOAvip English Wikipedia <ref>{{Cite pmid|33053024}}</ref> Sindrome do desconforto respiratorio agudo associada a COVID-19 tratada com DEXametasona (CoDEX): delineamento e justificativa de um estudo randomizado #MMPMID33053024 Tomazini BM; Maia IS; Bueno FR; Silva MVAO; Baldassare FP; Costa ELV; Moura RAB; Honorato MO; Costa AN; Cavalcanti AB; Rosa RG; Avezum A; Veiga VC; Lopes RD; Damiani LP; Machado FR; Berwanger O; Azevedo LCP Rev Bras Ter Intensiva 2020[Jul]; 32 (3): 354-362 PMID33053024show ga OBJECTIVE: The infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spreads worldwide and is considered a pandemic. The most common manifestation of SARS-CoV-2 infection (coronavirus disease 2019 - COVID-19) is viral pneumonia with varying degrees of respiratory compromise and up to 40% of hospitalized patients might develop acute respiratory distress syndrome. Several clinical trials evaluated the role of corticosteroids in non-COVID-19 acute respiratory distress syndrome with conflicting results. We designed a trial to evaluate the effectiveness of early intravenous dexamethasone administration on the number of days alive and free of mechanical ventilation within 28 days after randomization in adult patients with moderate or severe acute respiratory distress syndrome due to confirmed or probable COVID-19. METHODS: This is a pragmatic, prospective, randomized, stratified, multicenter, open-label, controlled trial including 350 patients with early-onset (less than 48 hours before randomization) moderate or severe acute respiratory distress syndrome, defined by the Berlin criteria, due to COVID-19. Eligible patients will be randomly allocated to either standard treatment plus dexamethasone (Intervention Group) or standard treatment without dexamethasone (Control Group). Patients in the intervention group will receive dexamethasone 20mg intravenous once daily for 5 days, followed by dexamethasone 10mg IV once daily for additional 5 days or until intensive care unit discharge, whichever occurs first. The primary outcome is ventilator-free days within 28 days after randomization, defined as days alive and free from invasive mechanical ventilation. Secondary outcomes are all-cause mortality rates at day 28, evaluation of the clinical status at day 15 assessed with a 6-level ordinal scale, mechanical ventilation duration from randomization to day 28, Sequential Organ Failure Assessment Score evaluation at 48 hours, 72 hours and 7 days and intensive care unit -free days within 28. |*COVID-19 Drug Treatment[MESH] |*COVID-19/complications/epidemiology/physiopathology[MESH] |*Dexamethasone/administration & dosage[MESH] |*Glucocorticoids/administration & dosage[MESH] |*Respiratory Distress Syndrome/drug therapy/virology[MESH] |Adult[MESH] |Humans[MESH] |Intensive Care Units[MESH] |Multicenter Studies as Topic[MESH] |Organ Dysfunction Scores[MESH] |Pandemics[MESH] |Pragmatic Clinical Trials as Topic[MESH] |Prospective Studies[MESH] |Randomized Controlled Trials as Topic[MESH] |Respiration, Artificial[MESH]Sindrome do desconforto respiratorio agudo associada a COVID-19 tratad(epmc).pdf DeepDyve Pubget Overpricing