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10.1146/annurev-physiol-031620-093431 http://scihub22266oqcxt.onion/10.1146/annurev-physiol-031620-093431 33074771!7878360!33074771     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33074771.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Annu+Rev+Physiol 2021 ; 83 (ä): 39-58 Nephropedia Template TP {{tp|p=33074771|t=2021. Renal Denervation to Treat Heart Failure |pdf=|usr=}}{{33074771}} gab.com Text Renal Denervation to Treat Heart Failure JO: Annu Rev Physiol http://www.kidney.de/pget.php?&tw=1&pmid=33074771 #FOAvip Heart failure (HF) is a global pandemic with a poor prognosis after hospitalization. Despite HF syndrome complexities, evidence of significant sympathetic overactivity in the manifestation and progression of HF is universally accepted. Confirmation of this dogma is observed in guideline-directed use of neurohormonal pharmacotherapies as a standard of care in HF. Despite reductions in morbidity and mortality, a growing patient population is resistant to these medications, while off-target side effects lead to dismal patient adherence to lifelong drug regimens. Novel therapeutic strategies, devoid of these limitations, are necessary to attenuate the progression of HF pathophysiology while continuing to reduce morbidity and mortality. Renal denervation is an endovascular procedure, whereby the ablation of renal nerves results in reduced renal afferent and efferent sympathetic nerve activity in the kidney and globally. In this review, we discuss the current state of preclinical and clinical research related to renal sympathetic denervation to treat HF. Twit Text FOAVip Renal Denervation to Treat Heart Failure ????Annu Rev Physiol http://www.kidney.de/pget.php?&tw=1&pmid=33074771 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33074771 #FOAvip English Wikipedia <ref>{{Cite pmid|33074771}}</ref> Renal Denervation to Treat Heart Failure #MMPMID33074771 Sharp TE 3rd; Lefer DJ Annu Rev Physiol 2021[Feb]; 83 (ä): 39-58 PMID33074771show ga Heart failure (HF) is a global pandemic with a poor prognosis after hospitalization. Despite HF syndrome complexities, evidence of significant sympathetic overactivity in the manifestation and progression of HF is universally accepted. Confirmation of this dogma is observed in guideline-directed use of neurohormonal pharmacotherapies as a standard of care in HF. Despite reductions in morbidity and mortality, a growing patient population is resistant to these medications, while off-target side effects lead to dismal patient adherence to lifelong drug regimens. Novel therapeutic strategies, devoid of these limitations, are necessary to attenuate the progression of HF pathophysiology while continuing to reduce morbidity and mortality. Renal denervation is an endovascular procedure, whereby the ablation of renal nerves results in reduced renal afferent and efferent sympathetic nerve activity in the kidney and globally. In this review, we discuss the current state of preclinical and clinical research related to renal sympathetic denervation to treat HF. |Animals[MESH] |Disease Progression[MESH] |Heart Failure/physiopathology/*therapy[MESH] |Humans[MESH] |Kidney/physiopathology[MESH]Renal Denervation to Treat Heart Failure (epmc).pdf DeepDyve Pubget Overpricing