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10.1007/s40266-020-00808-4 http://scihub22266oqcxt.onion/10.1007/s40266-020-00808-4 33084001!7575413!33084001     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33084001&cmd=llinks): Failed to open stream: HTTP request failed! 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The Cross-Talk between Age, Hypertension and Inflammation in COVID-19 Patients: Therapeutic Targets |pdf=|usr=}}{{33084001}} gab.com Text The Cross-Talk between Age, Hypertension and Inflammation in COVID-19 Patients: Therapeutic Targets JO: Drugs Aging http://www.kidney.de/pget.php?&tw=1&pmid=33084001 #FOAvip This paper presents a brief overview of the complex interaction between age, hypertension, the renin-angiotensin-aldosterone system (RAAS), inflammation, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection. Coronavirus disease 2019 (COVID-19) is more frequent and more severe in comorbid elderly patients, especially those with hypertension, diabetes, obesity, or cardiovascular diseases. There are concerns regarding the use of RAAS inhibitors in patients with COVID-19. Some physicians have considered the need for interrupting RAAS inhibition in order to reduce the possibility of SARS-CoV2 entering lung cells after binding to angiotensin-converting enzyme 2 (ACE2) receptors. We offer a different point of view in relation to the need for continuing to use RAAS inhibitors in patients with COVID-19. We focused our article on elderly patients because of the distinctive imbalance between the immune response, which is depressed, and the exacerbated inflammatory response, 'inflammaging', which makes the geriatric patient an appropriate candidate for therapeutic strategies aimed at modulating the inflammatory response. Indeed, COVID-19 is an inflammatory storm that starts and worsens during the course of the disease. During the COVID-19 pandemic, various therapeutic approaches have been tested, including antiviral drugs, interferon, anti-interleukins, hydroxychloroquine, anti-inflammatories, immunoglobulins from recovered patients, and heparins. Some of these therapeutic approaches did not prove to be beneficial, or even induced serious complications. Based on current evidence, in the early stages of the disease modulation of the inflammatory response through the inhibition of neprilysin and modulation of the RAAS could affect the course and outcome of COVID-19. Twit Text FOAVip The Cross-Talk between Age, Hypertension and Inflammation in COVID-19 Patients: Therapeutic Targets ????Drugs Aging http://www.kidney.de/pget.php?&tw=1&pmid=33084001 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33084001 #FOAvip English Wikipedia <ref>{{Cite pmid|33084001}}</ref> The Cross-Talk between Age, Hypertension and Inflammation in COVID-19 Patients: Therapeutic Targets #MMPMID33084001 Casucci G; Acanfora D; Incalzi RA Drugs Aging 2020[Nov]; 37 (11): 779-785 PMID33084001show ga This paper presents a brief overview of the complex interaction between age, hypertension, the renin-angiotensin-aldosterone system (RAAS), inflammation, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) infection. Coronavirus disease 2019 (COVID-19) is more frequent and more severe in comorbid elderly patients, especially those with hypertension, diabetes, obesity, or cardiovascular diseases. There are concerns regarding the use of RAAS inhibitors in patients with COVID-19. Some physicians have considered the need for interrupting RAAS inhibition in order to reduce the possibility of SARS-CoV2 entering lung cells after binding to angiotensin-converting enzyme 2 (ACE2) receptors. We offer a different point of view in relation to the need for continuing to use RAAS inhibitors in patients with COVID-19. We focused our article on elderly patients because of the distinctive imbalance between the immune response, which is depressed, and the exacerbated inflammatory response, 'inflammaging', which makes the geriatric patient an appropriate candidate for therapeutic strategies aimed at modulating the inflammatory response. Indeed, COVID-19 is an inflammatory storm that starts and worsens during the course of the disease. During the COVID-19 pandemic, various therapeutic approaches have been tested, including antiviral drugs, interferon, anti-interleukins, hydroxychloroquine, anti-inflammatories, immunoglobulins from recovered patients, and heparins. Some of these therapeutic approaches did not prove to be beneficial, or even induced serious complications. Based on current evidence, in the early stages of the disease modulation of the inflammatory response through the inhibition of neprilysin and modulation of the RAAS could affect the course and outcome of COVID-19. |*Betacoronavirus/drug effects/physiology[MESH] |*Coronavirus Infections/drug therapy/immunology/metabolism/virology[MESH] |*Inflammation/drug therapy/immunology[MESH] |*Pandemics[MESH] |*Pneumonia, Viral/drug therapy/immunology/metabolism/virology[MESH] |Aged[MESH] |Angiotensin Receptor Antagonists/*pharmacology[MESH] |Angiotensin-Converting Enzyme 2[MESH] |Angiotensin-Converting Enzyme Inhibitors/*pharmacology[MESH] |COVID-19[MESH] |Cytokine Release Syndrome/drug therapy/immunology[MESH] |Humans[MESH] |Hypertension/*drug therapy[MESH] |Immunologic Factors/pharmacology[MESH] |Neprilysin/antagonists & inhibitors[MESH] |Peptidyl-Dipeptidase A/metabolism[MESH] |Renin-Angiotensin System/drug effects[MESH]The Cross-Talk between Age, Hypertension and Inflammation in COVID-19 (epmc).pdf DeepDyve Pubget Overpricing