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10.1080/07391102.2020.1840439 http://scihub22266oqcxt.onion/10.1080/07391102.2020.1840439 33140706!7651195!33140706     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33140706&cmd=llinks): Failed to open stream: HTTP request failed! 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Targeting the initiation and termination codons of SARS-CoV-2 spike protein as possible therapy against COVID-19: the role of novel harpagide 5-O-beta-D-glucopyranoside from Clerodendrum volubile P Beauv (Labiatae) |pdf=|usr=}}{{33140706}} gab.com Text Targeting the initiation and termination codons of SARS-CoV-2 spike protein as possible therapy against COVID-19: the role of novel harpagide 5-O-beta-D-glucopyranoside from Clerodendrum volubile P Beauv (Labiatae) JO: J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=33140706 #FOAvip The global spread of the coronavirus infections disease - 2019 (COVID-19) and the search for new drugs from natural products particularly from plants are receiving much attention recently. In this study, the therapeutic potential of a new iridoid glycoside isolated from the leaves of Clerodendrum volubile against COVID-19 was investigated. Harpagide 5-O-beta-D-glucopyranoside (HG) was isolated, characterised and investigated for its druglikeness, optimized geometry, and pharmacokinetics properties. Its immunomodulatory was determined by chemiluminescence assay using polymorphonuclear neutrophils (PMNs) in addition to T-cell proliferation assay. In silico analysis was used in determining its molecular interaction with severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). HG displayed potent druglikeness properties, with no inhibitory effect on cytochrome P(450) (1A2, 2C19, 2C9, 2D6 and 3A4) and a predicted LD(50) of 2000 mg/kg. Its (1)H-NMR chemical shifts showed a little deviation of 0.01 and 0.11 ppm for H-4 and H-9, respectively. HG significantly suppressed oxidative bursts in PMNs, while concomitantly inhibiting T-cell proliferation. It also displayed a very strong binding affinity with the translation initiation and termination sequence sites of spike (S) protein mRNA of SARS-COV-2, its gene product, and host ACE2 receptor. These results suggest the immunomodulatory properties and anti-SARS-COV-2 potentials of HG which can be explored in the treatment and management of COVID-19.Communicated by Ramaswamy H. Sarma. Twit Text FOAVip Targeting the initiation and termination codons of SARS-CoV-2 spike protein as possible therapy against COVID-19: the role of novel harpagide 5-O-beta-D-glucopyranoside from Clerodendrum volubile P Beauv (Labiatae) ????J Biomol Struct Dyn http://www.kidney.de/pget.php?&tw=1&pmid=33140706 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33140706 #FOAvip English Wikipedia <ref>{{Cite pmid|33140706}}</ref> Targeting the initiation and termination codons of SARS-CoV-2 spike protein as possible therapy against COVID-19: the role of novel harpagide 5-O-beta-D-glucopyranoside from Clerodendrum volubile P Beauv (Labiatae) #MMPMID33140706 Erukainure OL; Atolani O; Muhammad A; Katsayal SB; Ebhuoma OO; Ibeji CU; Mesaik MA J Biomol Struct Dyn 2022[Apr]; 40 (6): 2475-2488 PMID33140706show ga The global spread of the coronavirus infections disease - 2019 (COVID-19) and the search for new drugs from natural products particularly from plants are receiving much attention recently. In this study, the therapeutic potential of a new iridoid glycoside isolated from the leaves of Clerodendrum volubile against COVID-19 was investigated. Harpagide 5-O-beta-D-glucopyranoside (HG) was isolated, characterised and investigated for its druglikeness, optimized geometry, and pharmacokinetics properties. Its immunomodulatory was determined by chemiluminescence assay using polymorphonuclear neutrophils (PMNs) in addition to T-cell proliferation assay. In silico analysis was used in determining its molecular interaction with severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). HG displayed potent druglikeness properties, with no inhibitory effect on cytochrome P(450) (1A2, 2C19, 2C9, 2D6 and 3A4) and a predicted LD(50) of 2000 mg/kg. Its (1)H-NMR chemical shifts showed a little deviation of 0.01 and 0.11 ppm for H-4 and H-9, respectively. HG significantly suppressed oxidative bursts in PMNs, while concomitantly inhibiting T-cell proliferation. It also displayed a very strong binding affinity with the translation initiation and termination sequence sites of spike (S) protein mRNA of SARS-COV-2, its gene product, and host ACE2 receptor. These results suggest the immunomodulatory properties and anti-SARS-COV-2 potentials of HG which can be explored in the treatment and management of COVID-19.Communicated by Ramaswamy H. Sarma. |*Clerodendrum/chemistry[MESH] |*Spike Glycoprotein, Coronavirus/chemistry[MESH] |COVID-19 Drug Treatment[MESH] |Codon, Terminator[MESH] |Glucosides/*pharmacology[MESH] |Humans[MESH] |Iridoid Glycosides/*pharmacology[MESH] |Pyrans[MESH]Targeting the initiation and termination codons of SARS-CoV-2 spike pr(epmc).pdf DeepDyve Pubget Overpricing