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10.1111/febs.15620 http://scihub22266oqcxt.onion/10.1111/febs.15620 33142020!ä!33142020 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33142020.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       FEBS+J 2021 ; 288 (12): 3799-3812 Nephropedia Template TP {{tp|p=33142020|t=2021. Energy sources that fuel metabolic processes in protruding finger-like organelles |pdf=|usr=}}{{33142020}} gab.com Text Energy sources that fuel metabolic processes in protruding finger-like organelles JO: FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=33142020 #FOAvip Cells possess a variety of organelles with characteristic structure and subcellular localization intimately linked to their specific function. While most are intracellular and found in virtually all eukaryotic cells, there is a small group of organelles of elongated cylindrical shapes in highly specialized cells that protrude into the extracellular space, such as cilia, flagella, and microvilli. The ATP required by intracellular organelles is amply available in the cytosol, largely generated by mitochondria. However, such is not the case for cilia and flagella, whose slender structures cannot accommodate mitochondria. These organelles consume massive amounts of ATP to carry out high energy-demanding functions, such as sensory transduction or motility. ATP from the nearest mitochondria or other reactions within the cell body is severely limited by diffusion and generally insufficient to fuel the entire length of cilia and flagella. These organelles overcome this fuel restriction by local generation of ATP, using mechanisms that vary depending on the nutrients that are available in their particular external environment. Here, we review, with emphasis in mammals, the remarkable adaptations that cilia and flagella use to fuel their metabolic needs. Additionally, we discuss how a decrease in nutrients surrounding olfactory cilia might impair olfaction in COVID-19 patients. Twit Text FOAVip Energy sources that fuel metabolic processes in protruding finger-like organelles ????FEBS J http://www.kidney.de/pget.php?&tw=1&pmid=33142020 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33142020 #FOAvip English Wikipedia <ref>{{Cite pmid|33142020}}</ref> Energy sources that fuel metabolic processes in protruding finger-like organelles #MMPMID33142020 Villar PS; Vergara C; Bacigalupo J FEBS J 2021[Jun]; 288 (12): 3799-3812 PMID33142020show ga Cells possess a variety of organelles with characteristic structure and subcellular localization intimately linked to their specific function. While most are intracellular and found in virtually all eukaryotic cells, there is a small group of organelles of elongated cylindrical shapes in highly specialized cells that protrude into the extracellular space, such as cilia, flagella, and microvilli. The ATP required by intracellular organelles is amply available in the cytosol, largely generated by mitochondria. However, such is not the case for cilia and flagella, whose slender structures cannot accommodate mitochondria. These organelles consume massive amounts of ATP to carry out high energy-demanding functions, such as sensory transduction or motility. ATP from the nearest mitochondria or other reactions within the cell body is severely limited by diffusion and generally insufficient to fuel the entire length of cilia and flagella. These organelles overcome this fuel restriction by local generation of ATP, using mechanisms that vary depending on the nutrients that are available in their particular external environment. Here, we review, with emphasis in mammals, the remarkable adaptations that cilia and flagella use to fuel their metabolic needs. Additionally, we discuss how a decrease in nutrients surrounding olfactory cilia might impair olfaction in COVID-19 patients. |Adenosine Triphosphate/*metabolism[MESH] |Animals[MESH] |COVID-19/metabolism/virology[MESH] |Cilia/*metabolism[MESH] |Flagella/*metabolism[MESH] |Humans[MESH] |Mitochondria/metabolism[MESH] |Models, Biological[MESH] |Organelles/*metabolism[MESH]Energy sources that fuel metabolic processes in protruding finger-like(epmc).pdf DeepDyve Pubget Overpricing