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10.3390/molecules25215091 http://scihub22266oqcxt.onion/10.3390/molecules25215091 33147850!7662214!33147850     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33147850&cmd=llinks): Failed to open stream: HTTP request failed! 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Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation |pdf=|usr=}}{{33147850}} gab.com Text Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation JO: Molecules http://www.kidney.de/pget.php?&tw=1&pmid=33147850 #FOAvip Zebrafish has been a reliable model system for studying human viral pathologies. SARS-CoV-2 viral infection has become a global chaos, affecting millions of people. There is an urgent need to contain the pandemic and develop reliable therapies. We report the use of a humanized zebrafish model, xeno-transplanted with human lung epithelial cells, A549, for studying the protective effects of a tri-herbal medicine Coronil. At human relevant doses of 12 and 58 microg/kg, Coronil inhibited SARS-CoV-2 spike protein, induced humanized zebrafish mortality, and rescued from behavioral fever. Morphological and cellular abnormalities along with granulocyte and macrophage accumulation in the swim bladder were restored to normal. Skin hemorrhage, renal cell degeneration, and necrosis were also significantly attenuated by Coronil treatment. Ultra-high-performance liquid chromatography (UHPLC) analysis identified ursolic acid, betulinic acid, withanone, withaferine A, withanoside IV-V, cordifolioside A, magnoflorine, rosmarinic acid, and palmatine as phyto-metabolites present in Coronil. In A549 cells, Coronil attenuated the IL-1beta induced IL-6 and TNF-alpha cytokine secretions, and decreased TNF-alpha induced NF-kappaB/AP-1 transcriptional activity. Taken together, we show the disease modifying immunomodulatory properties of Coronil, at human equivalent doses, in rescuing the pathological features induced by the SARS-CoV-2 spike protein, suggesting its potential use in SARS-CoV-2 infectivity. Twit Text FOAVip Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation ????Molecules http://www.kidney.de/pget.php?&tw=1&pmid=33147850 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33147850 #FOAvip English Wikipedia <ref>{{Cite pmid|33147850}}</ref> Application of Humanized Zebrafish Model in the Suppression of SARS-CoV-2 Spike Protein Induced Pathology by Tri-Herbal Medicine Coronil via Cytokine Modulation #MMPMID33147850 Balkrishna A; Solleti SK; Verma S; Varshney A Molecules 2020[Nov]; 25 (21): ä PMID33147850show ga Zebrafish has been a reliable model system for studying human viral pathologies. SARS-CoV-2 viral infection has become a global chaos, affecting millions of people. There is an urgent need to contain the pandemic and develop reliable therapies. We report the use of a humanized zebrafish model, xeno-transplanted with human lung epithelial cells, A549, for studying the protective effects of a tri-herbal medicine Coronil. At human relevant doses of 12 and 58 microg/kg, Coronil inhibited SARS-CoV-2 spike protein, induced humanized zebrafish mortality, and rescued from behavioral fever. Morphological and cellular abnormalities along with granulocyte and macrophage accumulation in the swim bladder were restored to normal. Skin hemorrhage, renal cell degeneration, and necrosis were also significantly attenuated by Coronil treatment. Ultra-high-performance liquid chromatography (UHPLC) analysis identified ursolic acid, betulinic acid, withanone, withaferine A, withanoside IV-V, cordifolioside A, magnoflorine, rosmarinic acid, and palmatine as phyto-metabolites present in Coronil. In A549 cells, Coronil attenuated the IL-1beta induced IL-6 and TNF-alpha cytokine secretions, and decreased TNF-alpha induced NF-kappaB/AP-1 transcriptional activity. Taken together, we show the disease modifying immunomodulatory properties of Coronil, at human equivalent doses, in rescuing the pathological features induced by the SARS-CoV-2 spike protein, suggesting its potential use in SARS-CoV-2 infectivity. |Air Sacs/drug effects/virology[MESH] |Animals[MESH] |Anti-Inflammatory Agents, Non-Steroidal/therapeutic use[MESH] |Antiviral Agents/*therapeutic use[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Chromatography, High Pressure Liquid/methods[MESH] |Coronavirus Infections/*drug therapy/pathology/physiopathology[MESH] |Disease Models, Animal[MESH] |Fever/drug therapy/etiology[MESH] |Hemorrhage/prevention & control[MESH] |Humans[MESH] |Interleukin-6/metabolism[MESH] |Kidney/drug effects[MESH] |Necrosis/pathology/prevention & control[MESH] |Pandemics[MESH] |Phytotherapy[MESH] |Plant Extracts/*therapeutic use[MESH] |Pneumonia, Viral/*drug therapy/pathology/physiopathology[MESH] |Respiratory Mucosa/transplantation[MESH] |Spike Glycoprotein, Coronavirus/*antagonists & inhibitors[MESH] |Transcriptional Activation/drug effects[MESH] |Tumor Necrosis Factor-alpha/metabolism[MESH]Application of Humanized Zebrafish Model in the Suppression of SARS-Co(epmc).pdf DeepDyve Pubget Overpricing