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10.1186/s12974-020-01977-0 http://scihub22266oqcxt.onion/10.1186/s12974-020-01977-0 33158438!7645903!33158438     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33158438.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Neuroinflammation 2020 ; 17 (1): 334 Nephropedia Template TP {{tp|p=33158438|t=2020. Air pollution as a contributor to the inflammatory activity of multiple sclerosis |pdf=|usr=}}{{33158438}} gab.com Text Air pollution as a contributor to the inflammatory activity of multiple sclerosis JO: J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=33158438 #FOAvip OBJECTIVE: Air pollution has been recently identified as a risk factor for multiple sclerosis. Aim of this study was to investigate the immunological mechanism underlying the clinical association between air pollution, namely exposure to particulate matter 10 (PM10), and inflammatory activity of multiple sclerosis (MS) METHODS: Daily recording of PM10 was obtained by monitors depending on the residence of subjects. Expression of molecules involved in activation, adhesion, and migration of T lymphocytes were tested by flow cytometry in 57 MS patients and 19 healthy controls. We next assessed in vitro the effect of PM10 on expression of C-C chemokine receptors 6 (CCR6) by peripheral blood mononuclear cells (PBMCs), on cytokine production by monocyte-derived dendritic cells (mdDC), and on T cell polarization in PBMC/mdDC mixed cultures. RESULTS: We identified a significant correlation between mean PM10 levels and expression of CCR6 CD4+ T circulating cells in MS patients. This was paralleled by the observation in vitro of a higher level of CCR6 expression on PBMC following treatment with increased doses of particulate matter. Moreover, in mdDC cultures, particulate matter induced the secretion by mdDC of Th17 polarizing IL1 beta, IL6, and IL23 and, in mdDC/PBMC mixed cultures, enhanced generation of IL17-producing T cells. CONCLUSIONS: Ex vivo and in vitro studies support the pro-inflammatory role of PM in MS, by upregulating expression of CCR6 on circulating CD4+ T cells and inducing in innate immune cells the production of Th17 polarizing cytokines. Therefore, we speculate that in MS respiratory exposure to PM10 may induce the production in the lung of autoreactive Th17 lymphocytes and boost their migratory properties through the blood-brain barrier. Twit Text FOAVip Air pollution as a contributor to the inflammatory activity of multiple sclerosis ????J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=33158438 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33158438 #FOAvip English Wikipedia <ref>{{Cite pmid|33158438}}</ref> Air pollution as a contributor to the inflammatory activity of multiple sclerosis #MMPMID33158438 Cortese A; Lova L; Comoli P; Volpe E; Villa S; Mallucci G; La Salvia S; Romani A; Franciotta D; Bollati V; Basso S; Guido I; Quartuccio G; Battistini L; Cereda C; Bergamaschi R J Neuroinflammation 2020[Nov]; 17 (1): 334 PMID33158438show ga OBJECTIVE: Air pollution has been recently identified as a risk factor for multiple sclerosis. Aim of this study was to investigate the immunological mechanism underlying the clinical association between air pollution, namely exposure to particulate matter 10 (PM10), and inflammatory activity of multiple sclerosis (MS) METHODS: Daily recording of PM10 was obtained by monitors depending on the residence of subjects. Expression of molecules involved in activation, adhesion, and migration of T lymphocytes were tested by flow cytometry in 57 MS patients and 19 healthy controls. We next assessed in vitro the effect of PM10 on expression of C-C chemokine receptors 6 (CCR6) by peripheral blood mononuclear cells (PBMCs), on cytokine production by monocyte-derived dendritic cells (mdDC), and on T cell polarization in PBMC/mdDC mixed cultures. RESULTS: We identified a significant correlation between mean PM10 levels and expression of CCR6 CD4+ T circulating cells in MS patients. This was paralleled by the observation in vitro of a higher level of CCR6 expression on PBMC following treatment with increased doses of particulate matter. Moreover, in mdDC cultures, particulate matter induced the secretion by mdDC of Th17 polarizing IL1 beta, IL6, and IL23 and, in mdDC/PBMC mixed cultures, enhanced generation of IL17-producing T cells. CONCLUSIONS: Ex vivo and in vitro studies support the pro-inflammatory role of PM in MS, by upregulating expression of CCR6 on circulating CD4+ T cells and inducing in innate immune cells the production of Th17 polarizing cytokines. Therefore, we speculate that in MS respiratory exposure to PM10 may induce the production in the lung of autoreactive Th17 lymphocytes and boost their migratory properties through the blood-brain barrier. |Adult[MESH] |Air Pollution/*adverse effects[MESH] |Cells, Cultured[MESH] |Female[MESH] |Humans[MESH] |Inflammation Mediators/*blood[MESH] |Inflammation/blood/chemically induced/diagnosis[MESH] |Leukocytes, Mononuclear/drug effects/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Multiple Sclerosis/*blood/*chemically induced/diagnosis[MESH]Air pollution as a contributor to the inflammatory activity of multipl(epmc).pdf DeepDyve Pubget Overpricing