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10.1371/journal.ppat.1008949 http://scihub22266oqcxt.onion/10.1371/journal.ppat.1008949 33180882!7660522!33180882     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33180882.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       PLoS+Pathog 2020 ; 16 (11): e1008949 Nephropedia Template TP {{tp|p=33180882|t=2020. Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques: A nonhuman primate model of COVID-19 progression |pdf=|usr=}}{{33180882}} gab.com Text Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques: A nonhuman primate model of COVID-19 progression JO: PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33180882 #FOAvip The COVID-19 has emerged as an epidemic, causing severe pneumonia with a high infection rate globally. To better understand the pathogenesis caused by SARS-CoV-2, we developed a rhesus macaque model to mimic natural infection via the nasal route, resulting in the SARS-CoV-2 virus shedding in the nose and stool up to 27 days. Importantly, we observed the pathological progression of marked interstitial pneumonia in the infected animals on 5-7 dpi, with virus dissemination widely occurring in the lower respiratory tract and lymph nodes, and viral RNA was consistently detected from 5 to 21 dpi. During the infection period, the kinetics response of T cells was revealed to contribute to COVID-19 progression. Our findings implied that the antiviral response of T cells was suppressed after 3 days post infection, which might be related to increases in the Treg cell population in PBMCs. Moreover, two waves of the enhanced production of cytokines (TGF-alpha, IL-4, IL-6, GM-CSF, IL-10, IL-15, IL-1beta), chemokines (MCP-1/CCL2, IL-8/CXCL8, and MIP-1beta/CCL4) were detected in lung tissue. Our data collected from this model suggested that T cell response and cytokine/chemokine changes in lung should be considered as evaluation parameters for COVID-19 treatment and vaccine development, besides of observation of virus shedding and pathological analysis. Twit Text FOAVip Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques: A nonhuman primate model of COVID-19 progression ????PLoS Pathog http://www.kidney.de/pget.php?&tw=1&pmid=33180882 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33180882 #FOAvip English Wikipedia <ref>{{Cite pmid|33180882}}</ref> Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques: A nonhuman primate model of COVID-19 progression #MMPMID33180882 Zheng H; Li H; Guo L; Liang Y; Li J; Wang X; Hu Y; Wang L; Liao Y; Yang F; Li Y; Fan S; Li D; Cui P; Wang Q; Shi H; Chen Y; Yang Z; Yang J; Shen D; Cun W; Zhou X; Dong X; Wang Y; Chen Y; Dai Q; Jin W; He Z; Li Q; Liu L PLoS Pathog 2020[Nov]; 16 (11): e1008949 PMID33180882show ga The COVID-19 has emerged as an epidemic, causing severe pneumonia with a high infection rate globally. To better understand the pathogenesis caused by SARS-CoV-2, we developed a rhesus macaque model to mimic natural infection via the nasal route, resulting in the SARS-CoV-2 virus shedding in the nose and stool up to 27 days. Importantly, we observed the pathological progression of marked interstitial pneumonia in the infected animals on 5-7 dpi, with virus dissemination widely occurring in the lower respiratory tract and lymph nodes, and viral RNA was consistently detected from 5 to 21 dpi. During the infection period, the kinetics response of T cells was revealed to contribute to COVID-19 progression. Our findings implied that the antiviral response of T cells was suppressed after 3 days post infection, which might be related to increases in the Treg cell population in PBMCs. Moreover, two waves of the enhanced production of cytokines (TGF-alpha, IL-4, IL-6, GM-CSF, IL-10, IL-15, IL-1beta), chemokines (MCP-1/CCL2, IL-8/CXCL8, and MIP-1beta/CCL4) were detected in lung tissue. Our data collected from this model suggested that T cell response and cytokine/chemokine changes in lung should be considered as evaluation parameters for COVID-19 treatment and vaccine development, besides of observation of virus shedding and pathological analysis. |Animals[MESH] |Betacoronavirus/*pathogenicity[MESH] |COVID-19[MESH] |COVID-19 Drug Treatment[MESH] |Coronavirus Infections/drug therapy/*pathology/virology[MESH] |Cytokines/immunology[MESH] |Disease Models, Animal[MESH] |Lung/immunology/pathology[MESH] |Macaca mulatta[MESH] |Pandemics[MESH] |Pneumonia, Viral/*pathology/virology[MESH] |SARS-CoV-2[MESH] |Viral Load/methods[MESH] |Virulence[MESH]Virulence and pathogenesis of SARS-CoV-2 infection in rhesus macaques:(epmc).pdf DeepDyve Pubget Overpricing