Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.3389/fimmu.2020.575074 http://scihub22266oqcxt.onion/10.3389/fimmu.2020.575074 33193365!7604353!33193365     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33193365.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Immunol 2020 ; 11 (ä): 575074 Nephropedia Template TP {{tp|p=33193365|t=2020. Measurement of Cellular Immune Response to Viral Infection and Vaccination |pdf=|usr=}}{{33193365}} gab.com Text Measurement of Cellular Immune Response to Viral Infection and Vaccination JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33193365 #FOAvip Combined cellular and humoral host immune response determine the clinical course of a viral infection and effectiveness of vaccination, but currently the cellular immune response cannot be measured on simple blood samples. As functional activity of immune cells is determined by coordinated activity of signaling pathways, we developed mRNA-based JAK-STAT signaling pathway activity assays to quantitatively measure the cellular immune response on Affymetrix expression microarray data of various types of blood samples from virally infected patients (influenza, RSV, dengue, yellow fever, rotavirus) or vaccinated individuals, and to determine vaccine immunogenicity. JAK-STAT1/2 pathway activity was increased in blood samples of patients with viral, but not bacterial, infection and was higher in influenza compared to RSV-infected patients, reflecting known differences in immunogenicity. High JAK-STAT3 pathway activity was associated with more severe RSV infection. In contrast to inactivated influenza virus vaccine, live yellow fever vaccine did induce JAK-STAT1/2 pathway activity in blood samples, indicating superior immunogenicity. Normal (healthy) JAK-STAT1/2 pathway activity was established, enabling assay interpretation without the need for a reference sample. The JAK-STAT pathway assays enable measurement of cellular immune response for prognosis, therapy stratification, vaccine development, and clinical testing. Twit Text FOAVip Measurement of Cellular Immune Response to Viral Infection and Vaccination ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=33193365 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33193365 #FOAvip English Wikipedia <ref>{{Cite pmid|33193365}}</ref> Measurement of Cellular Immune Response to Viral Infection and Vaccination #MMPMID33193365 Bouwman W; Verhaegh W; Holtzer L; van de Stolpe A Front Immunol 2020[]; 11 (ä): 575074 PMID33193365show ga Combined cellular and humoral host immune response determine the clinical course of a viral infection and effectiveness of vaccination, but currently the cellular immune response cannot be measured on simple blood samples. As functional activity of immune cells is determined by coordinated activity of signaling pathways, we developed mRNA-based JAK-STAT signaling pathway activity assays to quantitatively measure the cellular immune response on Affymetrix expression microarray data of various types of blood samples from virally infected patients (influenza, RSV, dengue, yellow fever, rotavirus) or vaccinated individuals, and to determine vaccine immunogenicity. JAK-STAT1/2 pathway activity was increased in blood samples of patients with viral, but not bacterial, infection and was higher in influenza compared to RSV-infected patients, reflecting known differences in immunogenicity. High JAK-STAT3 pathway activity was associated with more severe RSV infection. In contrast to inactivated influenza virus vaccine, live yellow fever vaccine did induce JAK-STAT1/2 pathway activity in blood samples, indicating superior immunogenicity. Normal (healthy) JAK-STAT1/2 pathway activity was established, enabling assay interpretation without the need for a reference sample. The JAK-STAT pathway assays enable measurement of cellular immune response for prognosis, therapy stratification, vaccine development, and clinical testing. |*Immunity, Cellular[MESH] |Biomarkers/blood[MESH] |Dengue Vaccines/therapeutic use[MESH] |Dengue Virus/*immunology/pathogenicity[MESH] |Dengue/blood/immunology/prevention & control/virology[MESH] |Diagnosis, Differential[MESH] |Host-Pathogen Interactions[MESH] |Humans[MESH] |Immunogenicity, Vaccine[MESH] |Influenza Vaccines/therapeutic use[MESH] |Influenza, Human/blood/immunology/prevention & control/virology[MESH] |Oligonucleotide Array Sequence Analysis[MESH] |Orthomyxoviridae/*immunology/pathogenicity[MESH] |Predictive Value of Tests[MESH] |RNA, Messenger/blood/genetics[MESH] |Respiratory Syncytial Virus Infections/blood/immunology/prevention & control/virology[MESH] |Respiratory Syncytial Virus, Human/*immunology/pathogenicity[MESH] |Rotavirus Infections/blood/immunology/prevention & control/virology[MESH] |Rotavirus Vaccines[MESH] |Rotavirus/*immunology/pathogenicity[MESH] |Signal Transduction/genetics[MESH] |Viral Vaccines/*therapeutic use[MESH] |Virus Diseases/blood/*immunology/prevention & control/virology[MESH] |Yellow Fever Vaccine/therapeutic use[MESH] |Yellow Fever/blood/immunology/prevention & control/virology[MESH]Measurement of Cellular Immune Response to Viral Infection and Vaccina(epmc).pdf DeepDyve Pubget Overpricing