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Modelling intestinal inflammation and infection using mini-gut organoids #MMPMID33257835
Li VSW
Nat Rev Gastroenterol Hepatol 2021[Feb]; 18 (2): 89-90 PMID33257835show ga
In 2020, major advances to the understanding of gastrointestinal inflammatory and infectious disease have been made using 'mini-gut' organoids. Key findings include the discovery of somatic inflammatory gene mutations in ulcerative colitis epithelium, a unique mutational signature in colorectal cancer caused by genotoxic Escherichia coli, and infection of intestinal organoids by SARS-CoV-2.