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10.1152/ajpcell.00442.2020 http://scihub22266oqcxt.onion/10.1152/ajpcell.00442.2020 33326313!8294626!33326313     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33326313.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Cell+Physiol 2021 ; 320 (3): C392-C414 Nephropedia Template TP {{tp|p=33326313|t=2021. The H(+)-ATPase (V-ATPase): from proton pump to signaling complex in health and disease |pdf=|usr=}}{{33326313}} gab.com Text The H(+)-ATPase (V-ATPase): from proton pump to signaling complex in health and disease JO: Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=33326313 #FOAvip A primary function of the H(+)-ATPase (or V-ATPase) is to create an electrochemical proton gradient across eukaryotic cell membranes, which energizes fundamental cellular processes. Its activity allows for the acidification of intracellular vesicles and organelles, which is necessary for many essential cell biological events to occur. In addition, many specialized cell types in various organ systems such as the kidney, bone, male reproductive tract, inner ear, olfactory mucosa, and more, use plasma membrane V-ATPases to perform specific activities that depend on extracellular acidification. It is, however, increasingly apparent that V-ATPases are central players in many normal and pathophysiological processes that directly influence human health in many different and sometimes unexpected ways. These include cancer, neurodegenerative diseases, diabetes, and sensory perception, as well as energy and nutrient-sensing functions within cells. This review first covers the well-established role of the V-ATPase as a transmembrane proton pump in the plasma membrane and intracellular vesicles and outlines factors contributing to its physiological regulation in different cell types. This is followed by a discussion of the more recently emerging unconventional roles for the V-ATPase, such as its role as a protein interaction hub involved in cell signaling, and the (patho)physiological implications of these interactions. Finally, the central importance of endosomal acidification and V-ATPase activity on viral infection will be discussed in the context of the current COVID-19 pandemic. Twit Text FOAVip The H(+)-ATPase (V-ATPase): from proton pump to signaling complex in health and disease ????Am J Physiol Cell Physiol http://www.kidney.de/pget.php?&tw=1&pmid=33326313 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33326313 #FOAvip English Wikipedia <ref>{{Cite pmid|33326313}}</ref> The H(+)-ATPase (V-ATPase): from proton pump to signaling complex in health and disease #MMPMID33326313 Eaton AF; Merkulova M; Brown D Am J Physiol Cell Physiol 2021[Mar]; 320 (3): C392-C414 PMID33326313show ga A primary function of the H(+)-ATPase (or V-ATPase) is to create an electrochemical proton gradient across eukaryotic cell membranes, which energizes fundamental cellular processes. Its activity allows for the acidification of intracellular vesicles and organelles, which is necessary for many essential cell biological events to occur. In addition, many specialized cell types in various organ systems such as the kidney, bone, male reproductive tract, inner ear, olfactory mucosa, and more, use plasma membrane V-ATPases to perform specific activities that depend on extracellular acidification. It is, however, increasingly apparent that V-ATPases are central players in many normal and pathophysiological processes that directly influence human health in many different and sometimes unexpected ways. These include cancer, neurodegenerative diseases, diabetes, and sensory perception, as well as energy and nutrient-sensing functions within cells. This review first covers the well-established role of the V-ATPase as a transmembrane proton pump in the plasma membrane and intracellular vesicles and outlines factors contributing to its physiological regulation in different cell types. This is followed by a discussion of the more recently emerging unconventional roles for the V-ATPase, such as its role as a protein interaction hub involved in cell signaling, and the (patho)physiological implications of these interactions. Finally, the central importance of endosomal acidification and V-ATPase activity on viral infection will be discussed in the context of the current COVID-19 pandemic. |*SARS-CoV-2[MESH] |Angiotensin-Converting Enzyme 2/metabolism[MESH] |COVID-19/*virology[MESH] |Humans[MESH] |Proton-Translocating ATPases/genetics/*metabolism[MESH] |Signal Transduction[MESH]The H(+)-ATPase (V-ATPase): from proton pump to signaling complex in h(epmc).pdf DeepDyve Pubget Overpricing