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10.1007/s00428-020-02975-6 http://scihub22266oqcxt.onion/10.1007/s00428-020-02975-6 33411031!7789084!33411031     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33411031&cmd=llinks): Failed to open stream: HTTP request failed! 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Transbronchial biopsies histopathological findings leading to successful late steroid therapy in Covid-19 acute respiratory failure |pdf=|usr=}}{{33411031}} gab.com Text Transbronchial biopsies histopathological findings leading to successful late steroid therapy in Covid-19 acute respiratory failure JO: Virchows Arch http://www.kidney.de/pget.php?&tw=1&pmid=33411031 #FOAvip We present results from clinical, radiologic, gas exchange, lung mechanics, and fibre-optic bronchoscopy-guided transbronchial biopsies in a case of acute respiratory failure due to SARS-CoV-2 (Covid-19). This report highlights the pulmonary, immunological, and inflammatory changes found during acute diffuse alveolar damage and the later organizing phase. An early diffuse alveolar damage pattern with predominant epithelial involvement with active recruitment of T cells and monocytes was observed followed by a late organizing pattern with pneumocyte hyperplasia, inflammatory infiltration, prominent endotheliitis, and secondary germinal centers. The patient's deterioration paralleling the late immuno-pathological findings based the decision to administer intravenous corticosteroids, resulting in clinical, gasometric, and radiologic improvement. We believe that real-time clinicopathological correlation, along with the description of the immunological processes at play, will contribute to the full clinical picture of Covid-19 and might lead to a more rational approach in the precise timing of anti-inflammatory, anti-cytokine, or steroid therapies. Twit Text FOAVip Transbronchial biopsies histopathological findings leading to successful late steroid therapy in Covid-19 acute respiratory failure ????Virchows Arch http://www.kidney.de/pget.php?&tw=1&pmid=33411031 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33411031 #FOAvip English Wikipedia <ref>{{Cite pmid|33411031}}</ref> Transbronchial biopsies histopathological findings leading to successful late steroid therapy in Covid-19 acute respiratory failure #MMPMID33411031 Klein F; Soriano JC; Anfuso MB; Ruiz V; Perazzo M; Paladini H; Vigliano A; Osses J; Lowenstein P; Vigliano C; Caneva J Virchows Arch 2021[Oct]; 479 (4): 827-833 PMID33411031show ga We present results from clinical, radiologic, gas exchange, lung mechanics, and fibre-optic bronchoscopy-guided transbronchial biopsies in a case of acute respiratory failure due to SARS-CoV-2 (Covid-19). This report highlights the pulmonary, immunological, and inflammatory changes found during acute diffuse alveolar damage and the later organizing phase. An early diffuse alveolar damage pattern with predominant epithelial involvement with active recruitment of T cells and monocytes was observed followed by a late organizing pattern with pneumocyte hyperplasia, inflammatory infiltration, prominent endotheliitis, and secondary germinal centers. The patient's deterioration paralleling the late immuno-pathological findings based the decision to administer intravenous corticosteroids, resulting in clinical, gasometric, and radiologic improvement. We believe that real-time clinicopathological correlation, along with the description of the immunological processes at play, will contribute to the full clinical picture of Covid-19 and might lead to a more rational approach in the precise timing of anti-inflammatory, anti-cytokine, or steroid therapies. |*COVID-19 Drug Treatment[MESH] |Aged[MESH] |Alveolar Epithelial Cells/metabolism/virology[MESH] |Biopsy/methods[MESH] |Bronchi/*pathology/virology[MESH] |COVID-19/pathology/virology[MESH] |Humans[MESH] |Lung/pathology[MESH] |Male[MESH] |Pulmonary Alveoli/metabolism/virology[MESH] |Respiratory Insufficiency/drug therapy/pathology/virology[MESH] |SARS-CoV-2/isolation & purification[MESH]Transbronchial biopsies histopathological findings leading to success(epmc).pdf DeepDyve Pubget Overpricing