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10.1016/j.placenta.2021.01.008 http://scihub22266oqcxt.onion/10.1016/j.placenta.2021.01.008 33497931!7833196!33497931     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33497931&cmd=llinks): Failed to open stream: HTTP request failed! 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Increased placental expression of angiotensin-converting enzyme 2, the receptor of SARS-CoV-2, associated with hypoxia in twin anemia-polycythemia sequence (TAPS) |pdf=|usr=}}{{33497931}} gab.com Text Increased placental expression of angiotensin-converting enzyme 2, the receptor of SARS-CoV-2, associated with hypoxia in twin anemia-polycythemia sequence (TAPS) JO: Placenta http://www.kidney.de/pget.php?&tw=1&pmid=33497931 #FOAvip INTRODUCTION: Recent reports suggest SARS-CoV-2, the virus causing COVID-19, may be transmittable from pregnant mother to placenta and fetus, albeit rarely. The efficacy of vertical transmission of SARS-CoV-2 critically depends on the availability of its receptor, ACE2, in the placenta. In the present study, we tested the hypothesis that placental ACE2 expression is oxygenation-dependent by studying the expression of ACE2 and associated cell entry regulators in the monochorionic twin anemia-polycythemia (TAPS) placenta, a model of discordant placental oxygenation. METHODS: We performed a retrospective comparative immunohistochemical, immunofluorescence and Western blot analysis of ACE2, TMPRSS2 and Cathepsin B expression in anemic and polycythemic territories of TAPS placentas (N = 14). RESULTS: ACE2 protein levels were significantly higher in the anemic twin territories than in the corresponding polycythemic territories, associated with upregulation of the key ACE2-related cell entry regulators, TMPRSS2 and Cathepsin B, immunolocalized to villous trophoblastic and stromal cells. Cellular colocalization of ACE2 and TMPRSS2, suggestive of functionality of this cell entry axis, was demonstrated by double immunofluorescence studies. DISCUSSION: Placental hypoxia is associated with upregulation of ACE2 expression, concomitant with increased expression of its key cell entry proteases. ACE2-regulated placental functions, both infection- and non-infection related, may be highly oxygenation-dependent. Twit Text FOAVip Increased placental expression of angiotensin-converting enzyme 2, the receptor of SARS-CoV-2, associated with hypoxia in twin anemia-polycythemia sequence (TAPS) ????Placenta http://www.kidney.de/pget.php?&tw=1&pmid=33497931 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33497931 #FOAvip English Wikipedia <ref>{{Cite pmid|33497931}}</ref> Increased placental expression of angiotensin-converting enzyme 2, the receptor of SARS-CoV-2, associated with hypoxia in twin anemia-polycythemia sequence (TAPS) #MMPMID33497931 Mao Q; Chu S; Shapiro S; Bliss JM; De Paepe ME Placenta 2021[Feb]; 105 (�): 7-13 PMID33497931show ga INTRODUCTION: Recent reports suggest SARS-CoV-2, the virus causing COVID-19, may be transmittable from pregnant mother to placenta and fetus, albeit rarely. The efficacy of vertical transmission of SARS-CoV-2 critically depends on the availability of its receptor, ACE2, in the placenta. In the present study, we tested the hypothesis that placental ACE2 expression is oxygenation-dependent by studying the expression of ACE2 and associated cell entry regulators in the monochorionic twin anemia-polycythemia (TAPS) placenta, a model of discordant placental oxygenation. METHODS: We performed a retrospective comparative immunohistochemical, immunofluorescence and Western blot analysis of ACE2, TMPRSS2 and Cathepsin B expression in anemic and polycythemic territories of TAPS placentas (N = 14). RESULTS: ACE2 protein levels were significantly higher in the anemic twin territories than in the corresponding polycythemic territories, associated with upregulation of the key ACE2-related cell entry regulators, TMPRSS2 and Cathepsin B, immunolocalized to villous trophoblastic and stromal cells. Cellular colocalization of ACE2 and TMPRSS2, suggestive of functionality of this cell entry axis, was demonstrated by double immunofluorescence studies. DISCUSSION: Placental hypoxia is associated with upregulation of ACE2 expression, concomitant with increased expression of its key cell entry proteases. ACE2-regulated placental functions, both infection- and non-infection related, may be highly oxygenation-dependent. |*Pregnancy, Twin/metabolism[MESH] |Adult[MESH] |Anemia/complications/*metabolism/pathology[MESH] |Angiotensin-Converting Enzyme 2/*metabolism[MESH] |Case-Control Studies[MESH] |Cohort Studies[MESH] |Diseases in Twins/metabolism/pathology[MESH] |Female[MESH] |Fetal Diseases/*metabolism/pathology[MESH] |Humans[MESH] |Hypoxia/complications/*metabolism/pathology[MESH] |Immunohistochemistry[MESH] |Infant, Newborn[MESH] |Male[MESH] |Placenta/*metabolism/pathology[MESH] |Polycythemia/complications/*metabolism/pathology[MESH] |Pregnancy[MESH] |Retrospective Studies[MESH] |SARS-CoV-2/metabolism[MESH] |Serine Endopeptidases/metabolism[MESH]Increased placental expression of angiotensin-converting enzyme 2, the(epmc).pdf DeepDyve Pubget Overpricing