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10.15252/embj.2021107651

http://scihub22266oqcxt.onion/10.15252/embj.2021107651
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33576058!7917546!33576058
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suck abstract from ncbi


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pmid33576058      EMBO+J 2021 ; 40 (5): e107651
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  • Halting SARS-CoV-2: lung organoids step up to the plate #MMPMID33576058
  • Leibel SL; Sun X
  • EMBO J 2021[Mar]; 40 (5): e107651 PMID33576058show ga
  • Defining the pulmonary cell types infected by SARS-CoV-2 and finding ways to prevent subsequent tissue damage are key goals for controlling COVID-19. Recent work establishing a human lung organoid-derived air-liquid interface model permissive to SARS-CoV-2 infection identifies alveolar type II cells as the primary cell type infected, reports an infection-induced interferon response and demonstrates the effectiveness of interferon lambda 1 treatment in dampening lung infection.
  • |*Models, Biological[MESH]
  • |*Virus Replication[MESH]
  • |Alveolar Epithelial Cells/*metabolism/pathology/virology[MESH]
  • |COVID-19 Drug Treatment[MESH]
  • |COVID-19/*metabolism/pathology[MESH]
  • |Humans[MESH]
  • |Organoids/*metabolism/pathology/virology[MESH]


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