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10.1038/s41467-021-21034-5

http://scihub22266oqcxt.onion/10.1038/s41467-021-21034-5
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suck abstract from ncbi


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pmid33594041      Nat+Commun 2021 ; 12 (1): 780
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  • Predicting mammalian hosts in which novel coronaviruses can be generated #MMPMID33594041
  • Wardeh M; Baylis M; Blagrove MSC
  • Nat Commun 2021[Feb]; 12 (1): 780 PMID33594041show ga
  • Novel pathogenic coronaviruses - such as SARS-CoV and probably SARS-CoV-2 - arise by homologous recombination between co-infecting viruses in a single cell. Identifying possible sources of novel coronaviruses therefore requires identifying hosts of multiple coronaviruses; however, most coronavirus-host interactions remain unknown. Here, by deploying a meta-ensemble of similarity learners from three complementary perspectives (viral, mammalian and network), we predict which mammals are hosts of multiple coronaviruses. We predict that there are 11.5-fold more coronavirus-host associations, over 30-fold more potential SARS-CoV-2 recombination hosts, and over 40-fold more host species with four or more different subgenera of coronaviruses than have been observed to date at >0.5 mean probability cut-off (2.4-, 4.25- and 9-fold, respectively, at >0.9821). Our results demonstrate the large underappreciation of the potential scale of novel coronavirus generation in wild and domesticated animals. We identify high-risk species for coronavirus surveillance.
  • |*Host-Pathogen Interactions[MESH]
  • |Animals[MESH]
  • |Coronavirus Infections/virology[MESH]
  • |Coronavirus/*physiology[MESH]
  • |Humans[MESH]
  • |Mammals/*virology[MESH]
  • |Models, Biological[MESH]
  • |Phylogeny[MESH]
  • |Recombination, Genetic/genetics[MESH]


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