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10.1021/acs.jnatprod.0c01243

http://scihub22266oqcxt.onion/10.1021/acs.jnatprod.0c01243
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33631936!ä!33631936

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suck abstract from ncbi


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pmid33631936      J+Nat+Prod 2021 ; 84 (2): 537-543
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  • Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp #MMPMID33631936
  • Xie X; Lu S; Pan X; Zou M; Li F; Lin H; Hu J; Fan S; He J
  • J Nat Prod 2021[Feb]; 84 (2): 537-543 PMID33631936show ga
  • A new bafilomycin derivative (1) and another seven known bafilomycins (2-8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC(50) values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.
  • |Animals[MESH]
  • |Antiviral Agents/*pharmacology[MESH]
  • |Dogs[MESH]
  • |Feces/*microbiology[MESH]
  • |Influenza A virus/drug effects[MESH]
  • |Macrolides/*pharmacology[MESH]
  • |Madin Darby Canine Kidney Cells[MESH]
  • |Proton-Translocating ATPases/*antagonists & inhibitors[MESH]
  • |SARS-CoV-2/drug effects[MESH]


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