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10.1016/j.clinre.2021.101639
http://scihub22266oqcxt.onion/10.1016/j.clinre.2021.101639
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 Clin+Res+Hepatol+Gastroenterol 2021 ; 45 (4): 101639
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Covid-19 in liver transplant recipients: the French SOT COVID registry #MMPMID33636654Dumortier J; Duvoux C; Roux O; Altieri M; Barraud H; Besch C; Caillard S; Coilly A; Conti F; Dharancy S; Durand F; Francoz C; Garaix F; Houssel-Debry P; Kounis I; Lassailly G; Laverdure N; Leroy V; Mallet M; Mazzola A; Meunier L; Radenne S; Richardet JP; Vanlemmens C; Hazzan M; Saliba FClin Res Hepatol Gastroenterol 2021[Jul]; 45 (4): 101639 PMID33636654show ga
BACKGROUND: Notwithstanding the ongoing coronavirus disease-2019 (Covid-19) pandemic, information on its clinical presentation and prognosis in organ transplant recipients remains limited. The aim of this registry-based observational study was to report the characteristics and clinical outcomes of liver transplant (LT) recipients included in the French nationwide Registry of Solid Organ Transplant Recipients with Covid-19. METHODS: COVID-19 was diagnosed in patients who had a positive PCR assay for SARS-CoV-2 or in presence of typical lung lesions on imaging or specific SARS-CoV-2 antibodies. Clinical and laboratory characteristics, management of immunosuppression, treatment for Covid-19, and clinical outcomes (hospitalization, admission to intensive care unit, mechanical ventilation, or death) were recorded. RESULTS: Of the 104 patients, 67 were admitted to hospital and 37 were managed at home (including all 13 children). Hospitalized patients had a median age of 65.2 years (IQR: 58.1?-?73.2 years) and two thirds were men. Most common comorbidities included overweight (67.3%), hypertension (61.2%), diabetes (50.7%), cardiovascular disease (20.9%) and respiratory disease (16.4%). SARS-CoV-2 infection was identified after a median of 92.8 months (IQR: 40.1?-?194.7 months) from LT. During hospitalization, antimetabolites, mTOR inhibitor, and CNIs were withdrawn in 41.9%, 30.0% and 12.5% of patients, respectively. The composite endpoint of severe Covid-19 within 30 days after diagnosis was reached by 33.0% of the adult patients. The 30-day mortality rate was 20.0%, and 28.1% for hospitalized patients. Multivariate analysis identified that age was independently associated with mortality. CONCLUSION: In our large nationwide study, Covid-19 in LT recipients was associated with a high mortality rate.|*Pandemics[MESH]|Adolescent[MESH]|Aged[MESH]|COVID-19 Nucleic Acid Testing[MESH]|COVID-19/diagnosis/*epidemiology/mortality/therapy[MESH]|Child[MESH]|Comorbidity[MESH]|Female[MESH]|France/epidemiology[MESH]|Hospitalization/statistics & numerical data[MESH]|Humans[MESH]|Immunosuppression Therapy[MESH]|Intensive Care Units[MESH]|Liver Transplantation/mortality/*statistics & numerical data[MESH]|Male[MESH]|Middle Aged[MESH]|Registries/*statistics & numerical data[MESH]|Respiration, Artificial/statistics & numerical data[MESH]|Risk Factors[MESH]
 
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