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10.1038/s41398-021-01287-w http://scihub22266oqcxt.onion/10.1038/s41398-021-01287-w 33741894!7976669!33741894     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33741894.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Transl+Psychiatry 2021 ; 11 (1): 179 Nephropedia Template TP {{tp|p=33741894|t=2021. Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure |pdf=|usr=}}{{33741894}} gab.com Text Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure JO: Transl Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=33741894 #FOAvip Microglia, the resident brain immune cells, play a critical role in normal brain development, and are impacted by the intrauterine environment, including maternal immune activation and inflammatory exposures. The COVID-19 pandemic presents a potential developmental immune challenge to the fetal brain, in the setting of maternal SARS-CoV-2 infection with its attendant potential for cytokine production and, in severe cases, cytokine storming. There is currently no biomarker or model for in utero microglial priming and function that might aid in identifying the neonates and children most vulnerable to neurodevelopmental morbidity, as microglia remain inaccessible in fetal life and after birth. This study aimed to generate patient-derived microglial-like cell models unique to each neonate from reprogrammed umbilical cord blood mononuclear cells, adapting and extending a novel methodology previously validated for adult peripheral blood mononuclear cells. We demonstrate that umbilical cord blood mononuclear cells can be used to create microglial-like cell models morphologically and functionally similar to microglia observed in vivo. We illustrate the application of this approach by generating microglia from cells exposed and unexposed to maternal SARS-CoV-2 infection. Our ability to create personalized neonatal models of fetal brain immune programming enables non-invasive insights into fetal brain development and potential childhood neurodevelopmental vulnerabilities for a range of maternal exposures, including COVID-19. Twit Text FOAVip Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure ????Transl Psychiatry http://www.kidney.de/pget.php?&tw=1&pmid=33741894 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33741894 #FOAvip English Wikipedia <ref>{{Cite pmid|33741894}}</ref> Umbilical cord blood-derived microglia-like cells to model COVID-19 exposure #MMPMID33741894 Sheridan SD; Thanos JM; De Guzman RM; McCrea LT; Horng JE; Fu T; Sellgren CM; Perlis RH; Edlow AG Transl Psychiatry 2021[Mar]; 11 (1): 179 PMID33741894show ga Microglia, the resident brain immune cells, play a critical role in normal brain development, and are impacted by the intrauterine environment, including maternal immune activation and inflammatory exposures. The COVID-19 pandemic presents a potential developmental immune challenge to the fetal brain, in the setting of maternal SARS-CoV-2 infection with its attendant potential for cytokine production and, in severe cases, cytokine storming. There is currently no biomarker or model for in utero microglial priming and function that might aid in identifying the neonates and children most vulnerable to neurodevelopmental morbidity, as microglia remain inaccessible in fetal life and after birth. This study aimed to generate patient-derived microglial-like cell models unique to each neonate from reprogrammed umbilical cord blood mononuclear cells, adapting and extending a novel methodology previously validated for adult peripheral blood mononuclear cells. We demonstrate that umbilical cord blood mononuclear cells can be used to create microglial-like cell models morphologically and functionally similar to microglia observed in vivo. We illustrate the application of this approach by generating microglia from cells exposed and unexposed to maternal SARS-CoV-2 infection. Our ability to create personalized neonatal models of fetal brain immune programming enables non-invasive insights into fetal brain development and potential childhood neurodevelopmental vulnerabilities for a range of maternal exposures, including COVID-19. |*Cellular Reprogramming[MESH] |*Induced Pluripotent Stem Cells[MESH] |Adult[MESH] |Brain/*growth & development/*immunology[MESH] |COVID-19/*immunology[MESH] |Female[MESH] |Fetal Blood/*immunology[MESH] |Humans[MESH] |Infant, Newborn[MESH] |Leukocytes, Mononuclear/*immunology[MESH] |Microglia/*immunology[MESH] |Pregnancy[MESH]Umbilical cord blood-derived microglia-like cells to model COVID-19 ex(epmc).pdf DeepDyve Pubget Overpricing