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10.1016/j.celrep.2021.108916 http://scihub22266oqcxt.onion/10.1016/j.celrep.2021.108916 33765414!7953434!33765414     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33765414.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cell+Rep 2021 ; 34 (13): 108916 Nephropedia Template TP {{tp|p=33765414|t=2021. Sarbecovirus ORF6 proteins hamper induction of interferon signaling |pdf=|usr=}}{{33765414}} gab.com Text Sarbecovirus ORF6 proteins hamper induction of interferon signaling JO: Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33765414 #FOAvip The presence of an ORF6 gene distinguishes sarbecoviruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other betacoronaviruses. Here we show that ORF6 inhibits induction of innate immune signaling, including upregulation of type I interferon (IFN) upon viral infection as well as type I and III IFN signaling. Intriguingly, ORF6 proteins from SARS-CoV-2 lineages are more efficient antagonists of innate immunity than their orthologs from SARS-CoV lineages. Mutational analyses identified residues E46 and Q56 as important determinants of the antagonistic activity of SARS-CoV-2 ORF6. Moreover, we show that the anti-innate immune activity of ORF6 depends on its C-terminal region and that ORF6 inhibits nuclear translocation of IRF3. Finally, we identify naturally occurring frameshift/nonsense mutations that result in an inactivating truncation of ORF6 in approximately 0.2% of SARS-CoV-2 isolates. Our findings suggest that ORF6 contributes to the poor IFN activation observed in individuals with coronavirus disease 2019 (COVID-19). Twit Text FOAVip Sarbecovirus ORF6 proteins hamper induction of interferon signaling ????Cell Rep http://www.kidney.de/pget.php?&tw=1&pmid=33765414 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33765414 #FOAvip English Wikipedia <ref>{{Cite pmid|33765414}}</ref> Sarbecovirus ORF6 proteins hamper induction of interferon signaling #MMPMID33765414 Kimura I; Konno Y; Uriu K; Hopfensperger K; Sauter D; Nakagawa S; Sato K Cell Rep 2021[Mar]; 34 (13): 108916 PMID33765414show ga The presence of an ORF6 gene distinguishes sarbecoviruses such as severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other betacoronaviruses. Here we show that ORF6 inhibits induction of innate immune signaling, including upregulation of type I interferon (IFN) upon viral infection as well as type I and III IFN signaling. Intriguingly, ORF6 proteins from SARS-CoV-2 lineages are more efficient antagonists of innate immunity than their orthologs from SARS-CoV lineages. Mutational analyses identified residues E46 and Q56 as important determinants of the antagonistic activity of SARS-CoV-2 ORF6. Moreover, we show that the anti-innate immune activity of ORF6 depends on its C-terminal region and that ORF6 inhibits nuclear translocation of IRF3. Finally, we identify naturally occurring frameshift/nonsense mutations that result in an inactivating truncation of ORF6 in approximately 0.2% of SARS-CoV-2 isolates. Our findings suggest that ORF6 contributes to the poor IFN activation observed in individuals with coronavirus disease 2019 (COVID-19). |Animals[MESH] |COVID-19/genetics/*metabolism[MESH] |Chlorocebus aethiops[MESH] |HEK293 Cells[MESH] |Humans[MESH] |Immunity, Innate/immunology[MESH] |Interferon Type I/*metabolism[MESH] |SARS-CoV-2/isolation & purification[MESH] |Signal Transduction/immunology[MESH] |Vero Cells[MESH]Sarbecovirus ORF6 proteins hamper induction of interferon signaling (epmc).pdf DeepDyve Pubget Overpricing