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10.3390/biom11040578 http://scihub22266oqcxt.onion/10.3390/biom11040578 33920915!8071227!33920915     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=33920915&cmd=llinks): Failed to open stream: HTTP request failed! 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The Emerging Role of Epigenetic Mechanisms in the Causation of Aberrant MMP Activity during Human Pathologies and the Use of Medicinal Drugs |pdf=|usr=}}{{33920915}} gab.com Text The Emerging Role of Epigenetic Mechanisms in the Causation of Aberrant MMP Activity during Human Pathologies and the Use of Medicinal Drugs JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=33920915 #FOAvip Matrix metalloproteinases (MMPs) cleave extracellular matrix proteins, growth factors, cytokines, and receptors to influence organ development, architecture, function, and the systemic and cell-specific responses to diseases and pharmacological drugs. Conversely, many diseases (such as atherosclerosis, arthritis, bacterial infections (tuberculosis), viral infections (COVID-19), and cancer), cholesterol-lowering drugs (such as statins), and tetracycline-class antibiotics (such as doxycycline) alter MMP activity through transcriptional, translational, and post-translational mechanisms. In this review, we summarize evidence that the aforementioned diseases and drugs exert significant epigenetic pressure on genes encoding MMPs, tissue inhibitors of MMPs, and factors that transcriptionally regulate the expression of MMPs. Our understanding of human pathologies associated with alterations in the proteolytic activity of MMPs must consider that these pathologies and their medicinal treatments may impose epigenetic pressure on the expression of MMP genes. Whether the epigenetic mechanisms affecting the activity of MMPs can be therapeutically targeted warrants further research. Twit Text FOAVip The Emerging Role of Epigenetic Mechanisms in the Causation of Aberrant MMP Activity during Human Pathologies and the Use of Medicinal Drugs ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=33920915 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33920915 #FOAvip English Wikipedia <ref>{{Cite pmid|33920915}}</ref> The Emerging Role of Epigenetic Mechanisms in the Causation of Aberrant MMP Activity during Human Pathologies and the Use of Medicinal Drugs #MMPMID33920915 Sarker H; Haimour A; Toor R; Fernandez-Patron C Biomolecules 2021[Apr]; 11 (4): ä PMID33920915show ga Matrix metalloproteinases (MMPs) cleave extracellular matrix proteins, growth factors, cytokines, and receptors to influence organ development, architecture, function, and the systemic and cell-specific responses to diseases and pharmacological drugs. Conversely, many diseases (such as atherosclerosis, arthritis, bacterial infections (tuberculosis), viral infections (COVID-19), and cancer), cholesterol-lowering drugs (such as statins), and tetracycline-class antibiotics (such as doxycycline) alter MMP activity through transcriptional, translational, and post-translational mechanisms. In this review, we summarize evidence that the aforementioned diseases and drugs exert significant epigenetic pressure on genes encoding MMPs, tissue inhibitors of MMPs, and factors that transcriptionally regulate the expression of MMPs. Our understanding of human pathologies associated with alterations in the proteolytic activity of MMPs must consider that these pathologies and their medicinal treatments may impose epigenetic pressure on the expression of MMP genes. Whether the epigenetic mechanisms affecting the activity of MMPs can be therapeutically targeted warrants further research. |*Drug Discovery[MESH] |Animals[MESH] |Anti-Bacterial Agents/*pharmacology/therapeutic use[MESH] |Bacterial Infections/drug therapy/genetics[MESH] |Bone Diseases/drug therapy/genetics[MESH] |COVID-19 Drug Treatment[MESH] |COVID-19/genetics[MESH] |Cardiovascular Diseases/drug therapy/genetics[MESH] |Epigenesis, Genetic/*drug effects[MESH] |Humans[MESH] |Hydroxymethylglutaryl-CoA Reductase Inhibitors/*pharmacology/therapeutic use[MESH] |Matrix Metalloproteinases/*genetics[MESH] |Molecular Targeted Therapy[MESH] |Neoplasms/drug therapy/genetics[MESH] |Tetracyclines/*pharmacology/therapeutic use[MESH]The Emerging Role of Epigenetic Mechanisms in the Causation of Aberran(epmc).pdf DeepDyve Pubget Overpricing