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10.3390/ijms22084152 http://scihub22266oqcxt.onion/10.3390/ijms22084152 33923792!8073364!33923792     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33923792.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Int+J+Mol+Sci 2021 ; 22 (8): ä Nephropedia Template TP {{tp|p=33923792|t=2021. Lymphopenia, Lymphopenia-Induced Proliferation, and Autoimmunity |pdf=|usr=}}{{33923792}} gab.com Text Lymphopenia, Lymphopenia-Induced Proliferation, and Autoimmunity JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33923792 #FOAvip Immune homeostasis is a tightly regulated system that is critical for defense against invasion by foreign pathogens and protection from self-reactivity for the survival of an individual. How the defects in this system might result in autoimmunity is discussed in this review. Reduced lymphocyte number, termed lymphopenia, can mediate lymphopenia-induced proliferation (LIP) to maintain peripheral lymphocyte numbers. LIP not only occurs in normal physiological conditions but also correlates with autoimmunity. Of note, lymphopenia is also a typical marker of immune aging, consistent with the fact that not only the autoimmunity increases in the elderly, but also autoimmune diseases (ADs) show characteristics of immune aging. Here, we discuss the types and rates of LIP in normal and autoimmune conditions, as well as the coronavirus disease 2019 in the context of LIP. Importantly, although the causative role of LIP has been demonstrated in the development of type 1 diabetes and rheumatoid arthritis, a two-hit model has suggested that the factors other than lymphopenia are required to mediate the loss of control over homeostasis to result in ADs. Interestingly, these factors may be, if not totally, related to the function/number of regulatory T cells which are key modulators to protect from self-reactivity. In this review, we summarize the important roles of lymphopenia/LIP and the Treg cells in various autoimmune conditions, thereby highlighting them as key therapeutic targets for autoimmunity treatments. Twit Text FOAVip Lymphopenia, Lymphopenia-Induced Proliferation, and Autoimmunity ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=33923792 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33923792 #FOAvip English Wikipedia <ref>{{Cite pmid|33923792}}</ref> Lymphopenia, Lymphopenia-Induced Proliferation, and Autoimmunity #MMPMID33923792 Sheu TT; Chiang BL Int J Mol Sci 2021[Apr]; 22 (8): ä PMID33923792show ga Immune homeostasis is a tightly regulated system that is critical for defense against invasion by foreign pathogens and protection from self-reactivity for the survival of an individual. How the defects in this system might result in autoimmunity is discussed in this review. Reduced lymphocyte number, termed lymphopenia, can mediate lymphopenia-induced proliferation (LIP) to maintain peripheral lymphocyte numbers. LIP not only occurs in normal physiological conditions but also correlates with autoimmunity. Of note, lymphopenia is also a typical marker of immune aging, consistent with the fact that not only the autoimmunity increases in the elderly, but also autoimmune diseases (ADs) show characteristics of immune aging. Here, we discuss the types and rates of LIP in normal and autoimmune conditions, as well as the coronavirus disease 2019 in the context of LIP. Importantly, although the causative role of LIP has been demonstrated in the development of type 1 diabetes and rheumatoid arthritis, a two-hit model has suggested that the factors other than lymphopenia are required to mediate the loss of control over homeostasis to result in ADs. Interestingly, these factors may be, if not totally, related to the function/number of regulatory T cells which are key modulators to protect from self-reactivity. In this review, we summarize the important roles of lymphopenia/LIP and the Treg cells in various autoimmune conditions, thereby highlighting them as key therapeutic targets for autoimmunity treatments. |Animals[MESH] |Autoimmune Diseases/*etiology/*immunology[MESH] |Autoimmunity/*immunology[MESH] |COVID-19/complications[MESH] |Cell Proliferation/physiology[MESH] |Homeostasis/immunology[MESH] |Humans[MESH] |Lymphopenia/*complications/*immunology[MESH]Lymphopenia, Lymphopenia-Induced Proliferation, and Autoimmunity (epmc).pdf DeepDyve Pubget Overpricing