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10.1038/s41598-021-88647-0 http://scihub22266oqcxt.onion/10.1038/s41598-021-88647-0 33927298!8085145!33927298     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33927298.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Sci+Rep 2021 ; 11 (1): 9277 Nephropedia Template TP {{tp|p=33927298|t=2021. A rotationally focused flow (RFF) microfluidic biosensor by density difference for early-stage detectable diagnosis |pdf=|usr=}}{{33927298}} gab.com Text A rotationally focused flow (RFF) microfluidic biosensor by density difference for early-stage detectable diagnosis JO: Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33927298 #FOAvip Label-free optical biosensors have received tremendous attention in point-of-care testing, especially in the emerging pandemic, COVID-19, since they advance toward early-detection, rapid, real-time, ease-of-use, and low-cost paradigms. Protein biomarkers testings require less sample modification process compared to nucleic-acid biomarkers'. However, challenges always are in detecting low-concentration for early-stage diagnosis. Here we present a Rotationally Focused Flow (RFF) method to enhance sensitivity(wavelength shift) of label-free optical sensors by increasing the detection probability of protein-based molecules. The RFF is structured by adding a less-dense fluid to focus the target-fluid in a T-shaped microchannel. It is integrated with label-free silicon microring resonators interacting with biotin-streptavidin. The suggested mechanism has demonstrated 0.19 fM concentration detection along with a significant magnitudes sensitivity enhancement compared to single flow methods. Verified by both CFD simulations and fluorescent flow-experiments, this study provides a promising proof-of-concept platform for next-generation lab-on-a-chip bioanalytics such as ultrafast and early-detection of COVID-19. Twit Text FOAVip A rotationally focused flow (RFF) microfluidic biosensor by density difference for early-stage detectable diagnosis ????Sci Rep http://www.kidney.de/pget.php?&tw=1&pmid=33927298 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33927298 #FOAvip English Wikipedia <ref>{{Cite pmid|33927298}}</ref> A rotationally focused flow (RFF) microfluidic biosensor by density difference for early-stage detectable diagnosis #MMPMID33927298 Kim N; Han K; Su PC; Kim I; Yoon YJ Sci Rep 2021[Apr]; 11 (1): 9277 PMID33927298show ga Label-free optical biosensors have received tremendous attention in point-of-care testing, especially in the emerging pandemic, COVID-19, since they advance toward early-detection, rapid, real-time, ease-of-use, and low-cost paradigms. Protein biomarkers testings require less sample modification process compared to nucleic-acid biomarkers'. However, challenges always are in detecting low-concentration for early-stage diagnosis. Here we present a Rotationally Focused Flow (RFF) method to enhance sensitivity(wavelength shift) of label-free optical sensors by increasing the detection probability of protein-based molecules. The RFF is structured by adding a less-dense fluid to focus the target-fluid in a T-shaped microchannel. It is integrated with label-free silicon microring resonators interacting with biotin-streptavidin. The suggested mechanism has demonstrated 0.19 fM concentration detection along with a significant magnitudes sensitivity enhancement compared to single flow methods. Verified by both CFD simulations and fluorescent flow-experiments, this study provides a promising proof-of-concept platform for next-generation lab-on-a-chip bioanalytics such as ultrafast and early-detection of COVID-19. |Biomarkers/metabolism[MESH] |Biosensing Techniques[MESH] |COVID-19/*diagnosis[MESH] |Early Diagnosis[MESH] |Humans[MESH] |Lab-On-A-Chip Devices[MESH] |Microfluidics/*methods[MESH] |SARS-CoV-2/*physiology[MESH]A rotationally focused flow (RFF) microfluidic biosensor by density di(epmc).pdf DeepDyve Pubget Overpricing