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10.1093/hmg/ddab130 http://scihub22266oqcxt.onion/10.1093/hmg/ddab130 33987664!8330913!33987664     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\33987664.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Hum+Mol+Genet 2021 ; 30 (16): 1521-1534 Nephropedia Template TP {{tp|p=33987664|t=2021. Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations |pdf=|usr=}}{{33987664}} gab.com Text Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations JO: Hum Mol Genet http://www.kidney.de/pget.php?&tw=1&pmid=33987664 #FOAvip It is important to study the genetics of complex traits in diverse populations. Here, we introduce covariate-adjusted linkage disequilibrium (LD) score regression (cov-LDSC), a method to estimate SNP-heritability ($\boldsymbolh_\boldsymbolg;\mathbf2)$ and its enrichment in homogenous and admixed populations with summary statistics and in-sample LD estimates. In-sample LD can be estimated from a subset of the genome-wide association studies samples, allowing our method to be applied efficiently to very large cohorts. In simulations, we show that unadjusted LDSC underestimates $\boldsymbolh_\boldsymbolg;\mathbf2$ by 10-60% in admixed populations; in contrast, cov-LDSC is robustly accurate. We apply cov-LDSC to genotyping data from 8124 individuals, mostly of admixed ancestry, from the Slim Initiative in Genomic Medicine for the Americas study, and to approximately 161 000 Latino-ancestry individuals, 47 000 African American-ancestry individuals and 135 000 European-ancestry individuals, as classified by 23andMe. We estimate $\boldsymbolh_\boldsymbolg;\mathbf2$ and detect heritability enrichment in three quantitative and five dichotomous phenotypes, making this, to our knowledge, the most comprehensive heritability-based analysis of admixed individuals to date. Most traits have high concordance of $\boldsymbolh_\boldsymbolg;\mathbf2$ and consistent tissue-specific heritability enrichment among different populations. However, for age at menarche, we observe population-specific heritability estimates of $\boldsymbolh_\boldsymbolg;\mathbf2$. We observe consistent patterns of tissue-specific heritability enrichment across populations; for example, in the limbic system for BMI, the per-standardized-annotation effect size $ \tau $* is 0.16 +/- 0.04, 0.28 +/- 0.11 and 0.18 +/- 0.03 in the Latino-, African American- and European-ancestry populations, respectively. Our approach is a powerful way to analyze genetic data for complex traits from admixed populations. Twit Text FOAVip Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations ????Hum Mol Genet http://www.kidney.de/pget.php?&tw=1&pmid=33987664 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=33987664 #FOAvip English Wikipedia <ref>{{Cite pmid|33987664}}</ref> Estimating heritability and its enrichment in tissue-specific gene sets in admixed populations #MMPMID33987664 Luo Y; Li X; Wang X; Gazal S; Mercader JM; Neale BM; Florez JC; Auton A; Price AL; Finucane HK; Raychaudhuri S Hum Mol Genet 2021[Jul]; 30 (16): 1521-1534 PMID33987664show ga It is important to study the genetics of complex traits in diverse populations. Here, we introduce covariate-adjusted linkage disequilibrium (LD) score regression (cov-LDSC), a method to estimate SNP-heritability ($\boldsymbolh_\boldsymbolg;\mathbf2)$ and its enrichment in homogenous and admixed populations with summary statistics and in-sample LD estimates. In-sample LD can be estimated from a subset of the genome-wide association studies samples, allowing our method to be applied efficiently to very large cohorts. In simulations, we show that unadjusted LDSC underestimates $\boldsymbolh_\boldsymbolg;\mathbf2$ by 10-60% in admixed populations; in contrast, cov-LDSC is robustly accurate. We apply cov-LDSC to genotyping data from 8124 individuals, mostly of admixed ancestry, from the Slim Initiative in Genomic Medicine for the Americas study, and to approximately 161 000 Latino-ancestry individuals, 47 000 African American-ancestry individuals and 135 000 European-ancestry individuals, as classified by 23andMe. We estimate $\boldsymbolh_\boldsymbolg;\mathbf2$ and detect heritability enrichment in three quantitative and five dichotomous phenotypes, making this, to our knowledge, the most comprehensive heritability-based analysis of admixed individuals to date. Most traits have high concordance of $\boldsymbolh_\boldsymbolg;\mathbf2$ and consistent tissue-specific heritability enrichment among different populations. However, for age at menarche, we observe population-specific heritability estimates of $\boldsymbolh_\boldsymbolg;\mathbf2$. We observe consistent patterns of tissue-specific heritability enrichment across populations; for example, in the limbic system for BMI, the per-standardized-annotation effect size $ \tau $* is 0.16 +/- 0.04, 0.28 +/- 0.11 and 0.18 +/- 0.03 in the Latino-, African American- and European-ancestry populations, respectively. Our approach is a powerful way to analyze genetic data for complex traits from admixed populations. |*Genetics, Population[MESH] |Genome-Wide Association Study/*statistics & numerical data[MESH] |Genotyping Techniques/statistics & numerical data[MESH] |Humans[MESH] |Linkage Disequilibrium/*genetics[MESH] |Multifactorial Inheritance/*genetics[MESH] |Phenotype[MESH] |Polymorphism, Single Nucleotide/genetics[MESH]Estimating heritability and its enrichment in tissue-specific gene set(epmc).pdf DeepDyve Pubget Overpricing