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10.1073/pnas.2106017118 http://scihub22266oqcxt.onion/10.1073/pnas.2106017118 34108245!8256008!34108245     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34108245&cmd=llinks): Failed to open stream: HTTP request failed! 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HIF-1alpha is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes |pdf=|usr=}}{{34108245}} gab.com Text HIF-1alpha is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=34108245 #FOAvip Patients with severe COVID-19 infection exhibit a low level of oxygen in affected tissue and blood. To understand the pathophysiology of COVID-19 infection, it is therefore necessary to understand cell function during hypoxia. We investigated aspects of human monocyte activation under hypoxic conditions. HMGB1 is an alarmin released by stressed cells. Under normoxic conditions, HMGB1 activates interferon regulatory factor (IRF)5 and nuclear factor-kappaB in monocytes, leading to expression of type I interferon (IFN) and inflammatory cytokines including tumor necrosis factor alpha, and interleukin 1beta, respectively. When hypoxic monocytes are activated by HMGB1, they produce proinflammatory cytokines but fail to produce type I IFN. Hypoxia-inducible factor-1alpha, induced by hypoxia, functions as a direct transcriptional repressor of IRF5 and IRF3. As hypoxia is a stressor that induces secretion of HMGB1 by epithelial cells, hypoxia establishes a microenvironment that favors monocyte production of inflammatory cytokines but not IFN. These findings have implications for the pathogenesis of COVID-19. Twit Text FOAVip HIF-1alpha is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=34108245 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34108245 #FOAvip English Wikipedia <ref>{{Cite pmid|34108245}}</ref> HIF-1alpha is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes #MMPMID34108245 Peng T; Du SY; Son M; Diamond B Proc Natl Acad Sci U S A 2021[Jun]; 118 (26): � PMID34108245show ga Patients with severe COVID-19 infection exhibit a low level of oxygen in affected tissue and blood. To understand the pathophysiology of COVID-19 infection, it is therefore necessary to understand cell function during hypoxia. We investigated aspects of human monocyte activation under hypoxic conditions. HMGB1 is an alarmin released by stressed cells. Under normoxic conditions, HMGB1 activates interferon regulatory factor (IRF)5 and nuclear factor-kappaB in monocytes, leading to expression of type I interferon (IFN) and inflammatory cytokines including tumor necrosis factor alpha, and interleukin 1beta, respectively. When hypoxic monocytes are activated by HMGB1, they produce proinflammatory cytokines but fail to produce type I IFN. Hypoxia-inducible factor-1alpha, induced by hypoxia, functions as a direct transcriptional repressor of IRF5 and IRF3. As hypoxia is a stressor that induces secretion of HMGB1 by epithelial cells, hypoxia establishes a microenvironment that favors monocyte production of inflammatory cytokines but not IFN. These findings have implications for the pathogenesis of COVID-19. |COVID-19/immunology[MESH] |Cell Hypoxia/*immunology[MESH] |Cells, Cultured[MESH] |Cytokines/immunology[MESH] |Humans[MESH] |Hypoxia-Inducible Factor 1, alpha Subunit/*immunology[MESH] |Interferon Regulatory Factors/metabolism[MESH] |Interferon Type I/immunology/metabolism[MESH] |Interleukin-1beta/metabolism[MESH] |Monocytes/*immunology/metabolism[MESH] |NF-kappa B/immunology/metabolism[MESH] |Oxygen/metabolism[MESH] |SARS-CoV-2/immunology[MESH]HIF-1alpha is a negative regulator of interferon regulatory factors: I(epmc).pdf DeepDyve Pubget Overpricing