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10.1084/jem.20210583 http://scihub22266oqcxt.onion/10.1084/jem.20210583 34128960!8210587!34128960     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34128960.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Exp+Med 2021 ; 218 (8): ä Nephropedia Template TP {{tp|p=34128960|t=2021. Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics |pdf=|usr=}}{{34128960}} gab.com Text Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics JO: J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=34128960 #FOAvip Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish infection, and the replication level correlates with the likelihood of viral transmission. Here, we examined the role of host innate immune defenses in restricting early SARS-CoV-2 infection using transcriptomics and biomarker-based tracking in serial patient nasopharyngeal samples and experiments with airway epithelial organoids. SARS-CoV-2 initially replicated exponentially, with a doubling time of approximately 6 h, and induced interferon-stimulated genes (ISGs) in the upper respiratory tract, which rose with viral replication and peaked just as viral load began to decline. Rhinovirus infection before SARS-CoV-2 exposure accelerated ISG responses and prevented SARS-CoV-2 replication. Conversely, blocking ISG induction during SARS-CoV-2 infection enhanced viral replication from a low infectious dose. These results show that the activity of ISG-mediated defenses at the time of SARS-CoV-2 exposure impacts infection progression and that the heterologous antiviral response induced by a different virus can protect against SARS-CoV-2. Twit Text FOAVip Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics ????J Exp Med http://www.kidney.de/pget.php?&tw=1&pmid=34128960 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34128960 #FOAvip English Wikipedia <ref>{{Cite pmid|34128960}}</ref> Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics #MMPMID34128960 Cheemarla NR; Watkins TA; Mihaylova VT; Wang B; Zhao D; Wang G; Landry ML; Foxman EF J Exp Med 2021[Aug]; 218 (8): ä PMID34128960show ga Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish infection, and the replication level correlates with the likelihood of viral transmission. Here, we examined the role of host innate immune defenses in restricting early SARS-CoV-2 infection using transcriptomics and biomarker-based tracking in serial patient nasopharyngeal samples and experiments with airway epithelial organoids. SARS-CoV-2 initially replicated exponentially, with a doubling time of approximately 6 h, and induced interferon-stimulated genes (ISGs) in the upper respiratory tract, which rose with viral replication and peaked just as viral load began to decline. Rhinovirus infection before SARS-CoV-2 exposure accelerated ISG responses and prevented SARS-CoV-2 replication. Conversely, blocking ISG induction during SARS-CoV-2 infection enhanced viral replication from a low infectious dose. These results show that the activity of ISG-mediated defenses at the time of SARS-CoV-2 exposure impacts infection progression and that the heterologous antiviral response induced by a different virus can protect against SARS-CoV-2. |Adult[MESH] |Aged[MESH] |Aged, 80 and over[MESH] |Angiotensin-Converting Enzyme 2/genetics[MESH] |COVID-19/*immunology/*virology[MESH] |Case-Control Studies[MESH] |Chemokine CXCL10/metabolism[MESH] |Disease Susceptibility/immunology[MESH] |Female[MESH] |Gene Expression Profiling[MESH] |Host-Pathogen Interactions/physiology[MESH] |Humans[MESH] |Immunity, Innate/*physiology[MESH] |Interferons/genetics/immunology/metabolism[MESH] |Male[MESH] |Middle Aged[MESH] |Nasopharynx/*virology[MESH] |Picornaviridae Infections/immunology/virology[MESH] |SARS-CoV-2/genetics/physiology[MESH] |Viral Load[MESH]Dynamic innate immune response determines susceptibility to SARS-CoV-2(epmc).pdf DeepDyve Pubget Overpricing