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10.1038/s41585-021-00477-x http://scihub22266oqcxt.onion/10.1038/s41585-021-00477-x 34131331!8204302!34131331     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34131331.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Rev+Urol 2021 ; 18 (8): 468-486 Nephropedia Template TP {{tp|p=34131331|t=2021. Molecular determinants of disease severity in urinary tract infection |pdf=|usr=}}{{34131331}} gab.com Text Molecular determinants of disease severity in urinary tract infection JO: Nat Rev Urol http://www.kidney.de/pget.php?&tw=1&pmid=34131331 #FOAvip The most common and lethal bacterial pathogens have co-evolved with the host. Pathogens are the aggressors, and the host immune system is responsible for the defence. However, immune responses can also become destructive, and excessive innate immune activation is a major cause of infection-associated morbidity, exemplified by symptomatic urinary tract infections (UTIs), which are caused, in part, by excessive innate immune activation. Severe kidney infections (acute pyelonephritis) are a major cause of morbidity and mortality, and painful infections of the urinary bladder (acute cystitis) can become debilitating in susceptible patients. Disease severity is controlled at specific innate immune checkpoints, and a detailed understanding of their functions is crucial for strategies to counter microbial aggression with novel treatment and prevention measures. One approach is the use of bacterial molecules that reprogramme the innate immune system, accelerating or inhibiting disease processes. A very different outcome is asymptomatic bacteriuria, defined by low host immune responsiveness to bacteria with attenuated virulence. This observation provides the rationale for immunomodulation as a new therapeutic tool to deliberately modify host susceptibility, control the host response and avoid severe disease. The power of innate immunity as an arbitrator of health and disease is also highly relevant for emerging pathogens, including the current COVID-19 pandemic. Twit Text FOAVip Molecular determinants of disease severity in urinary tract infection ????Nat Rev Urol http://www.kidney.de/pget.php?&tw=1&pmid=34131331 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34131331 #FOAvip English Wikipedia <ref>{{Cite pmid|34131331}}</ref> Molecular determinants of disease severity in urinary tract infection #MMPMID34131331 Ambite I; Butler D; Wan MLY; Rosenblad T; Tran TH; Chao SM; Svanborg C Nat Rev Urol 2021[Aug]; 18 (8): 468-486 PMID34131331show ga The most common and lethal bacterial pathogens have co-evolved with the host. Pathogens are the aggressors, and the host immune system is responsible for the defence. However, immune responses can also become destructive, and excessive innate immune activation is a major cause of infection-associated morbidity, exemplified by symptomatic urinary tract infections (UTIs), which are caused, in part, by excessive innate immune activation. Severe kidney infections (acute pyelonephritis) are a major cause of morbidity and mortality, and painful infections of the urinary bladder (acute cystitis) can become debilitating in susceptible patients. Disease severity is controlled at specific innate immune checkpoints, and a detailed understanding of their functions is crucial for strategies to counter microbial aggression with novel treatment and prevention measures. One approach is the use of bacterial molecules that reprogramme the innate immune system, accelerating or inhibiting disease processes. A very different outcome is asymptomatic bacteriuria, defined by low host immune responsiveness to bacteria with attenuated virulence. This observation provides the rationale for immunomodulation as a new therapeutic tool to deliberately modify host susceptibility, control the host response and avoid severe disease. The power of innate immunity as an arbitrator of health and disease is also highly relevant for emerging pathogens, including the current COVID-19 pandemic. |*Immunity, Innate[MESH] |Antibodies, Viral/*immunology[MESH] |COVID-19/*epidemiology/immunology[MESH] |Humans[MESH] |Pandemics[MESH] |SARS-CoV-2/*immunology[MESH] |Severity of Illness Index[MESH]Molecular determinants of disease severity in urinary tract infection (epmc).pdf DeepDyve Pubget Overpricing