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10.1007/s00384-021-03977-9

http://scihub22266oqcxt.onion/10.1007/s00384-021-03977-9
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34131784!8205311!34131784
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suck abstract from ncbi


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pmid34131784      Int+J+Colorectal+Dis 2021 ; 36 (9): 2051-2055
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  • Safety of biologics in inflammatory bowel disease patients with COVID-19 #MMPMID34131784
  • Weissman S; Aziz M; Smith WL; Elias S; Swaminath A; Feuerstein JD
  • Int J Colorectal Dis 2021[Sep]; 36 (9): 2051-2055 PMID34131784show ga
  • BACKGROUND: Patients with Inflammatory bowel disease (IBD) remain highly concerned that either their disease or medications-namely, biologics-may increase the risk of severe coronavirus-2019 (COVID-19). We aimed to assess the safety of biologics in Inflammatory bowel disease (IBD) patients with COVID-19. METHODS: We systematically reviewed multiple databases to find relevant articles reporting the effect of biologics on "severe" COVID-19 in IBD patients. Those in the form of case series (> 10 patients), case-control, and cohort studies were included. Severe COVID-19 was defined as intensive care unit (ICU) admission, mechanical ventilation, and/or mortality. Pooled analysis with multivariate regression was performed. RESULTS: A total of 12 studies with 2681 patients were included. The proportion of females was (48.3%, 95% confidence interval (CI) 47.0-49.5%). The proportion of UC patients was (44.8%, 95% CI 41.0-48.5%). Overall, in IBD patients, the need for mechanical ventilation, intensive care unit (ICU) admission, and mortality was 5.1%, 6.1%, and 4.5%, respectively. Use of biologics did not show a moderating effect on mechanical ventilation (p = 0.68), ICU admission (p = 0.27), or mortality (p = 0.20). CONCLUSIONS: Our findings advocate for the continued biologic therapy in IBD patients during the COVID-19 pandemic. Nevertheless, the incidence, severity, and outcomes related to COVID-19 in IBD patients' needs to be reassessed as data continues to emerge.
  • |*Biological Products/adverse effects[MESH]
  • |*COVID-19[MESH]
  • |*Inflammatory Bowel Diseases/drug therapy/epidemiology[MESH]
  • |Female[MESH]
  • |Humans[MESH]
  • |Pandemics[MESH]
  • |Risk Factors[MESH]


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