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10.1007/s11255-021-02920-9

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suck abstract from ncbi


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pmid34132971      Int+Urol+Nephrol 2022 ; 54 (1): 193-199
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  • Evaluation of central venous catheter and other risk factors for mortality in chronic hemodialysis patients with COVID-19 in Brazil #MMPMID34132971
  • Lugon JR; Neves PDMM; Pio-Abreu A; do Nascimento MM; Sesso R
  • Int Urol Nephrol 2022[Jan]; 54 (1): 193-199 PMID34132971show ga
  • PURPOSE: Hemodialysis patients with COVID-19 are at increased risk of death. We aimed to describe the characteristics of a cohort of Brazilian hemodialysis patients with COVID-19 and assess their mortality rate and risk factors for death. METHODS: Retrospective cohort study of 741 Brazilian hemodialysis patients with confirmed COVID-19 from Feb-Dec/2020, of 52 dialysis centers of the country. We analyzed comorbid conditions, sociodemographic factors, and dialysis-related parameters. To detect risk factors for mortality in hemodialysis patients, we performed multivariable Cox proportional hazard regression analysis. Survival was analyzed by Kaplan-Meier. RESULTS: From 9877 hemodialysis patients, 741 were diagnosed with COVID-19. Mean age was 57 +/- 16 years, 61% were male, and 51% white. The most frequent symptoms were fever (54.1%), cough (50.9%), and dyspnea (37.2%); 14.2% were asymptomatic. There were 139 deaths (18.8%), with 66% within the disease's first 15 days. 333 patients (44.9%) required hospitalization, and 211 (28.5%) were admitted to an intensive care unit. The cumulative probability of survival at 90 days of diagnosis was 79% (95% CI 76-82%). In the fully adjusted multivariate model, the risk factors significantly associated with death were diabetes mellitus (HR 1.52, 95% CI 1.05-2.19, P = 0.026), use of a central venous catheter (CVC) (HR 1.79, 95% CI 1.22-2.64, P = 0.003), age (HR 1.03, 95% CI 1.01-1.04, P < 0.001), and origin from the North vs. Southeast region (HR 2.60, 95% CI 1.01-6.68, P = 0.047). CONCLUSIONS: Hemodialysis patients using a CVC as the vascular access, aside from diabetic and elderly ones, should be closely monitored due to their high risk of death in the course of the COVID-19.
  • |Brazil/epidemiology[MESH]
  • |COVID-19/*epidemiology[MESH]
  • |Catheter-Related Infections/epidemiology/*etiology[MESH]
  • |Central Venous Catheters/*adverse effects[MESH]
  • |Comorbidity[MESH]
  • |Female[MESH]
  • |Follow-Up Studies[MESH]
  • |Humans[MESH]
  • |Incidence[MESH]
  • |Kidney Failure, Chronic/epidemiology/*therapy[MESH]
  • |Male[MESH]
  • |Middle Aged[MESH]
  • |Renal Dialysis/*adverse effects[MESH]
  • |Retrospective Studies[MESH]
  • |SARS-CoV-2[MESH]
  • |Survival Rate/trends[MESH]


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