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10.1007/s00210-021-02108-z

http://scihub22266oqcxt.onion/10.1007/s00210-021-02108-z
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suck abstract from ncbi


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pmid34151392      Naunyn+Schmiedebergs+Arch+Pharmacol 2021 ; 394 (7): 1589-1593
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  • The renin-angiotensin system and specifically angiotensin-converting enzyme 2 as a potential therapeutic target in SARS-CoV-2 infections #MMPMID34151392
  • Ferrara F; Vitiello A
  • Naunyn Schmiedebergs Arch Pharmacol 2021[Jul]; 394 (7): 1589-1593 PMID34151392show ga
  • In March 2019, the global COVID-19 pandemic caused by the novel SARS-CoV-2 coronavirus began. The first cases of SARS-CoV-2 infection occurred in November 19 in Wuhan, China. Preventive measures taken have not prevented the rapid spread of the virus to countries around the world. To date, there are approximately 3 million deaths, and a massive worldwide vaccination campaign has recently begun. SARS-CoV-2 uses the ACE-2 protein as an intracellular carrier. ACE-2 is a key component of the renin-angiotensin system (RAS), a key regulator of cardiovascular function. Considering the key role of ACE-2 in COVID-19 infection, both as an entry receptor and as a protective role, especially for the respiratory tract, and considering the variations of ACE-2 during the phases of viral infection, it is clear the important role that pharmacological regulation of RAS and ACE-2 may take. In this article, we describe the importance of ACE-2 in COVID-19 infection, the pharmacological aspects of a modulation with RAS-modifying agents, new therapeutic strategies, trying to provide a deep understanding and explanation of the complex mechanisms underlying the relationship between the virus and ACE-2, providing opinions and personal hypotheses on the best strategies of therapeutic intervention.
  • |*COVID-19 Drug Treatment[MESH]
  • |Angiotensin-Converting Enzyme 2/*metabolism/*therapeutic use[MESH]
  • |Animals[MESH]
  • |Antiviral Agents/*therapeutic use[MESH]
  • |COVID-19/enzymology/virology[MESH]
  • |Host-Pathogen Interactions[MESH]
  • |Humans[MESH]
  • |Recombinant Proteins/therapeutic use[MESH]
  • |Renin-Angiotensin System/*drug effects[MESH]
  • |SARS-CoV-2/*drug effects/pathogenicity[MESH]


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