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10.1007/s00439-021-02305-z http://scihub22266oqcxt.onion/10.1007/s00439-021-02305-z 34155559!8216591!34155559     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34155559&cmd=llinks): Failed to open stream: HTTP request failed! 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Association of CXCR6 with COVID-19 severity: delineating the host genetic factors in transcriptomic regulation |pdf=|usr=}}{{34155559}} gab.com Text Association of CXCR6 with COVID-19 severity: delineating the host genetic factors in transcriptomic regulation JO: Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=34155559 #FOAvip The coronavirus disease 2019 (COVID-19) is an infectious disease that mainly affects the host respiratory system with ~ 80% asymptomatic or mild cases and ~ 5% severe cases. Recent genome-wide association studies (GWAS) have identified several genetic loci associated with the severe COVID-19 symptoms. Delineating the genetic variants and genes is important for better understanding its biological mechanisms. We implemented integrative approaches, including transcriptome-wide association studies (TWAS), colocalization analysis, and functional element prediction analysis, to interpret the genetic risks using two independent GWAS datasets in lung and immune cells. To understand the context-specific molecular alteration, we further performed deep learning-based single-cell transcriptomic analyses on a bronchoalveolar lavage fluid (BALF) dataset from moderate and severe COVID-19 patients. We discovered and replicated the genetically regulated expression of CXCR6 and CCR9 genes. These two genes have a protective effect on lung, and a risk effect on whole blood, respectively. The colocalization analysis of GWAS and cis-expression quantitative trait loci highlighted the regulatory effect on CXCR6 expression in lung and immune cells. In the lung-resident memory CD8(+) T (T(RM)) cells, we found a 2.24-fold decrease of cell proportion among CD8(+) T cells and lower expression of CXCR6 in the severe patients than moderate patients. Pro-inflammatory transcriptional programs were highlighted in the T(RM) cellular trajectory from moderate to severe patients. CXCR6 from the 3p21.31 locus is associated with severe COVID-19. CXCR6 tends to have a lower expression in lung T(RM) cells of severe patients, which aligns with the protective effect of CXCR6 from TWAS analysis. Twit Text FOAVip Association of CXCR6 with COVID-19 severity: delineating the host genetic factors in transcriptomic regulation ????Hum Genet http://www.kidney.de/pget.php?&tw=1&pmid=34155559 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34155559 #FOAvip English Wikipedia <ref>{{Cite pmid|34155559}}</ref> Association of CXCR6 with COVID-19 severity: delineating the host genetic factors in transcriptomic regulation #MMPMID34155559 Dai Y; Wang J; Jeong HH; Chen W; Jia P; Zhao Z Hum Genet 2021[Sep]; 140 (9): 1313-1328 PMID34155559show ga The coronavirus disease 2019 (COVID-19) is an infectious disease that mainly affects the host respiratory system with ~ 80% asymptomatic or mild cases and ~ 5% severe cases. Recent genome-wide association studies (GWAS) have identified several genetic loci associated with the severe COVID-19 symptoms. Delineating the genetic variants and genes is important for better understanding its biological mechanisms. We implemented integrative approaches, including transcriptome-wide association studies (TWAS), colocalization analysis, and functional element prediction analysis, to interpret the genetic risks using two independent GWAS datasets in lung and immune cells. To understand the context-specific molecular alteration, we further performed deep learning-based single-cell transcriptomic analyses on a bronchoalveolar lavage fluid (BALF) dataset from moderate and severe COVID-19 patients. We discovered and replicated the genetically regulated expression of CXCR6 and CCR9 genes. These two genes have a protective effect on lung, and a risk effect on whole blood, respectively. The colocalization analysis of GWAS and cis-expression quantitative trait loci highlighted the regulatory effect on CXCR6 expression in lung and immune cells. In the lung-resident memory CD8(+) T (T(RM)) cells, we found a 2.24-fold decrease of cell proportion among CD8(+) T cells and lower expression of CXCR6 in the severe patients than moderate patients. Pro-inflammatory transcriptional programs were highlighted in the T(RM) cellular trajectory from moderate to severe patients. CXCR6 from the 3p21.31 locus is associated with severe COVID-19. CXCR6 tends to have a lower expression in lung T(RM) cells of severe patients, which aligns with the protective effect of CXCR6 from TWAS analysis. |*COVID-19/genetics/immunology[MESH] |*Receptors, CXCR6/genetics/immunology[MESH] |CD8-Positive T-Lymphocytes/*immunology[MESH] |Female[MESH] |Genome-Wide Association Study[MESH] |Humans[MESH] |Immunologic Memory/*genetics[MESH] |Lung/*immunology/virology[MESH] |Male[MESH] |Quantitative Trait Loci/*immunology[MESH] |Receptors, CCR/genetics/immunology[MESH] |Risk Factors[MESH] |SARS-CoV-2/*immunology[MESH] |Severity of Illness Index[MESH]Association of CXCR6 with COVID-19 severity: delineating the host gene(epmc).pdf DeepDyve Pubget Overpricing