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10.1002/anie.202103693 http://scihub22266oqcxt.onion/10.1002/anie.202103693 34161644!8426693!34161644     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=34161644&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\34161644.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Angew+Chem+Int+Ed+Engl 2021 ; 60 (35): 19191-19200 Nephropedia Template TP {{tp|p=34161644|t=2021. Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS-CoV-2 Genome |pdf=|usr=}}{{34161644}} gab.com Text Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS-CoV-2 Genome JO: Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=34161644 #FOAvip SARS-CoV-2 contains a positive single-stranded RNA genome of approximately 30 000 nucleotides. Within this genome, 15 RNA elements were identified as conserved between SARS-CoV and SARS-CoV-2. By nuclear magnetic resonance (NMR) spectroscopy, we previously determined that these elements fold independently, in line with data from in vivo and ex-vivo structural probing experiments. These elements contain non-base-paired regions that potentially harbor ligand-binding pockets. Here, we performed an NMR-based screening of a poised fragment library of 768 compounds for binding to these RNAs, employing three different (1) H-based 1D NMR binding assays. The screening identified common as well as RNA-element specific hits. The results allow selection of the most promising of the 15 RNA elements as putative drug targets. Based on the identified hits, we derive key functional units and groups in ligands for effective targeting of the RNA of SARS-CoV-2. Twit Text FOAVip Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS-CoV-2 Genome ????Angew Chem Int Ed Engl http://www.kidney.de/pget.php?&tw=1&pmid=34161644 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=34161644 #FOAvip English Wikipedia <ref>{{Cite pmid|34161644}}</ref> Exploring the Druggability of Conserved RNA Regulatory Elements in the SARS-CoV-2 Genome #MMPMID34161644 Sreeramulu S; Richter C; Berg H; Wirtz Martin MA; Ceylan B; Matzel T; Adam J; Altincekic N; Azzaoui K; Bains JK; Blommers MJJ; Ferner J; Furtig B; Gobel M; Grun JT; Hengesbach M; Hohmann KF; Hymon D; Knezic B; Martins JN; Mertinkus KR; Niesteruk A; Peter SA; Pyper DJ; Qureshi NS; Scheffer U; Schlundt A; Schnieders R; Stirnal E; Sudakov A; Troster A; Vogele J; Wacker A; Weigand JE; Wirmer-Bartoschek J; Wohnert J; Schwalbe H Angew Chem Int Ed Engl 2021[Aug]; 60 (35): 19191-19200 PMID34161644show ga SARS-CoV-2 contains a positive single-stranded RNA genome of approximately 30 000 nucleotides. Within this genome, 15 RNA elements were identified as conserved between SARS-CoV and SARS-CoV-2. By nuclear magnetic resonance (NMR) spectroscopy, we previously determined that these elements fold independently, in line with data from in vivo and ex-vivo structural probing experiments. These elements contain non-base-paired regions that potentially harbor ligand-binding pockets. Here, we performed an NMR-based screening of a poised fragment library of 768 compounds for binding to these RNAs, employing three different (1) H-based 1D NMR binding assays. The screening identified common as well as RNA-element specific hits. The results allow selection of the most promising of the 15 RNA elements as putative drug targets. Based on the identified hits, we derive key functional units and groups in ligands for effective targeting of the RNA of SARS-CoV-2. |*Genome[MESH] |Drug Evaluation, Preclinical[MESH] |Ligands[MESH] |Molecular Structure[MESH] |Nucleic Acid Conformation[MESH] |Proton Magnetic Resonance Spectroscopy[MESH] |RNA, Viral/chemistry/*metabolism[MESH] |SARS-CoV-2/*genetics[MESH]Exploring the Druggability of Conserved RNA Regulatory Elements in the(epmc).pdf DeepDyve Pubget Overpricing